Gene
mbtd1
- ID
- ZDB-GENE-060810-138
- Name
- mbt domain containing 1
- Symbol
- mbtd1 Nomenclature History
- Previous Names
-
- im:7159307 (1)
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable zinc ion binding activity. Predicted to act upstream of or within chromatin organization and regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in telencephalon. Orthologous to human MBTD1 (mbt domain containing 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7159307 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa2643 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa22144 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa42070 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa45467 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | FCS-type zinc finger superfamily | Mbt repeat | Polycomb group and chromatin remodeling factors | Zinc finger, FCS-type |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1QHB4 | InterPro | 649 | ||||
| UniProtKB:A0A8M2BGV5 | InterPro | 705 | ||||
| UniProtKB:E7F7F5 | InterPro | 705 | ||||
| UniProtKB:A0A8M9QN18 | InterPro | 649 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-13L14 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7159307 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068224799 (1) | 5183 nt | ||
| Genomic | GenBank:BX088589 (1) | 242558 nt | ||
| Polypeptide | UniProtKB:A0A8M2BGV5 (1) | 705 aa |
- Comparative Orthology
- Alliance
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Desvignes, T., Contreras, A., Postlethwait, J.H. (2014) Evolution of the miR199-214 cluster and vertebrate skeletal development. RNA Biology. 11(4):281-94
- Huang, H.T., Kathrein, K.L., Barton, A., Gitlin, Z., Huang, Y.H., Ward, T.P., Hofmann, O., Dibiase, A., Song, A., Tyekucheva, S., Hide, W., Zhou, Y., and Zon, L.I. (2013) A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nature cell biology. 15(12):1516-1525
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