Gene
itgav
- ID
- ZDB-GENE-060616-382
- Name
- integrin, alpha V
- Symbol
- itgav Nomenclature History
- Previous Names
-
- zgc:136222 (1)
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable integrin binding activity. Acts upstream of or within several processes, including Kupffer's vesicle development; chordate embryonic development; and gastrulation. Part of integrin complex. Is expressed in several structures, including axis; cardiovascular system; diencephalon; head; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm and acute myeloid leukemia. Orthologous to human ITGAV (integrin subunit alpha V).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb743 | Allele with multiple variants | Unknown | Unknown | not specified | |
| ihb744 | Allele with one insertion | Exon 12 | Unknown | CRISPR | |
| la016467Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa31703 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34569 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa41365 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| ui12 | Allele with one insertion | Exon 1 | Unknown | CRISPR | |
| ui13 | Allele with one deletion | Exon 2 | Unknown | CRISPR | |
| yzu7Et | Transgenic insertion | Unknown | Unknown | DNA |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-itgav | Gao et al., 2022 | |
| CRISPR2-itgav | Gao et al., 2022 | |
| CRISPR3-itgav | Zebrafish Nomenclature Committee | |
| CRISPR4-itgav | Ghasempour et al., 2024 | |
| MO1-itgav | N/A | (3) |
| MO2-itgav | N/A | Ablooglu et al., 2010 |
| MO3-itgav | N/A | Ablooglu et al., 2010 |
| MO4-itgav | N/A | Liu et al., 2012 |
| MO5-itgav | N/A | (4) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018184 | Integrin alpha chain, C-terminal cytoplasmic region, conserved site |
| Domain | IPR013649 | Integrin alpha, first immunoglubulin-like domain |
| Domain | IPR048285 | Integrin alpha, second immunoglobulin-like domain |
| Domain | IPR048286 | Integrin alpha, third immunoglobulin-like domain |
| Family | IPR000413 | Integrin alpha chain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | FG-GAP repeat | Integrin alpha beta-propellor | Integrin alpha chain | Integrin alpha chain, C-terminal cytoplasmic region, conserved site | Integrin alpha, first immunoglubulin-like domain | Integrin alpha, N-terminal | Integrin alpha, second immunoglobulin-like domain | Integrin alpha, third immunoglobulin-like domain | Integrin domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q3LTM3 | InterPro | 1045 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-69O16 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:136222 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195124 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001033721 (1) | 4301 nt | ||
| Genomic | GenBank:CU468956 (1) | 156034 nt | ||
| Polypeptide | UniProtKB:Q3LTM3 (1) | 1045 aa |
- Chen, Y.C., Martins, T.A., Marchica, V., Panula, P. (2024) Angiopoietin 1 and integrin beta 1b are vital for zebrafish brain development. Frontiers in Cellular Neuroscience. 17:12897941289794
- Ghasempour, S., Warner, N., Guan, R., Rodari, M.M., Ivanochko, D., Whittaker Hawkins, R., Marwaha, A., Nowak, J.K., Liang, Y., Mulder, D.J., Stallard, L., Li, M., Yu, D.D., Pluthero, F.G., Batura, V., Zhao, M., Siddiqui, I., Upton, J.E.M., Hulst, J.M., Kahr, W.H.A., Mendoza-Londono, R., Charbit-Henrion, F., Hoefsloot, L.H., Khiat, A., Moreira, D., Trindade, E., Espinheira, M.D.C., Pinto Pais, I., Weerts, M.J.A., Douben, H., Kotlarz, D., Snapper, S.B., Klein, C., Dowling, J.J., Julien, J.P., Joosten, M., Cerf-Bensussan, N., Freeman, S.A., Parlato, M., van Ham, T.J., Muise, A.M. (2024) Human ITGAV variants are associated with immune dysregulation, brain abnormalities, and colitis. The Journal of experimental medicine. 221(12):
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Hipke, K., Pitter, B., Hruscha, A., van Bebber, F., Modic, M., Bansal, V., Lewandowski, S.A., Orozco, D., Edbauer, D., Bonn, S., Haass, C., Pohl, U., Montanez, E., Schmid, B. (2023) Loss of TDP-43 causes ectopic endothelial sprouting and migration defects through increased fibronectin, vcam 1 and integrin α4/β1. Frontiers in cell and developmental biology. 11:11699621169962
- Gao, Y., Hu, B., Flores, R., Xie, H., Lin, F. (2022) Fibronectin and Integrin α5 play overlapping and independent roles in regulating the development of pharyngeal endoderm and cartilage. Developmental Biology. 489:122-133
- Jia, W., Guan, Z., Shi, S., Xiang, K., Chen, P., Tan, F., Ullah, N., Diaby, M., Guo, M., Song, C., Gao, B. (2022) The Annotation of Zebrafish Enhancer Trap Lines Generated with PB Transposon. Current issues in molecular biology. 44:2614-2621
- Li, L., Yang, W., Shen, Y., Xu, X., Li, J. (2020) Fish complement C8 evolution, functional network analyses, and the theoretical interaction between C8 alpha chain and CD59. Molecular immunology. 128:235-248
- Saddala, M.S., Lennikov, A., Bouras, A., Huang, H. (2020) RNA-Seq reveals differential expression profiles and functional annotation of genes involved in retinal degeneration in Pde6c mutant Danio rerio. BMC Genomics. 21:132
- Xue, Y., Liu, D., Cui, G., Ding, Y., Ai, D., Gao, S., Zhang, Y., Suo, S., Wang, X., Lv, P., Zhou, C., Li, Y., Chen, X., Peng, G., Jing, N., Han, J.J., Liu, F. (2019) A 3D Atlas of Hematopoietic Stem and Progenitor Cell Expansion by Multi-dimensional RNA-Seq Analysis. Cell Reports. 27:1567-1578.e5
- Jessen, T.N., Jessen, J.R. (2018) VANGL2 protein stability is regulated by integrin αv and the extracellular matrix. Experimental cell research. 374(1):128-139
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