Gene
mov10b.2
- ID
- ZDB-GENE-060526-371
- Name
- Mov10 RNA helicase b, tandem duplicate 2
- Symbol
- mov10b.2 Nomenclature History
- Previous Names
-
- si:dkeyp-38g6.3
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable RNA binding activity. Predicted to be involved in miRNA-mediated gene silencing by mRNA destabilization. Predicted to act upstream of or within regulatory ncRNA-mediated gene silencing. Predicted to be located in P-body. Predicted to be active in P granule and cytosol. Is expressed in eye; gill; heart; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human MOV10 (Mov10 RNA helicase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Yang et al., 2022
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la026476Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa510 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa7140 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa9008 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa17096 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34422 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 6 of 6
Show
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR026122 | Helicase MOV-10/SDE3, DEXXQ/H-box helicase domain |
| Domain | IPR041677 | DNA2/NAM7 helicase, helicase domain |
| Domain | IPR041679 | DNA2/NAM7 helicase-like, C-terminal |
| Domain | IPR047187 | Upf1-like, C-terminal helicase domain |
| Domain | IPR049075 | Helicase MOV-10, N-terminal |
1 - 5 of 9 Show all
Domain Details Per Protein
| Protein | Additional Resources | Length | DNA2/NAM7 helicase, helicase domain | DNA2/NAM7 helicase-like, C-terminal | Helicase MOV-10, helical domain | Helicase MOV-10, Ig-like domain | Helicase MOV-10-like, beta-barrel domain | Helicase MOV-10, N-terminal | Helicase MOV-10/SDE3, DEXXQ/H-box helicase domain | P-loop containing nucleoside triphosphate hydrolase | Upf1-like, C-terminal helicase domain |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q1LXK5 | InterPro | 1015 |
1 - 1 of 1
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mov10b.2-201
(1)
|
Ensembl | 3,131 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-38G6 | ZFIN Curated Data |
1 - 1 of 1
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001044340 (1) | 3048 nt | ||
| Genomic | GenBank:BX248319 (1) | 193173 nt | ||
| Polypeptide | UniProtKB:Q1LXK5 (1) | 1015 aa |
- Yang, S., Zhang, X., Li, X., Yin, X., Teng, L., Ji, G., Li, H. (2022) Evolutionary and Expression Analysis of MOV10 and MOV10L1 Reveals Their Origin, Duplication and Divergence. International Journal of Molecular Sciences. 23(14):
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Briolat, V., Jouneau, L., Carvalho, R., Palha, N., Langevin, C., Herbomel, P., Schwartz, O., Spaink, H.P., Levraud, J.P., Boudinot, P. (2014) Contrasted Innate Responses to Two Viruses in Zebrafish: Insights into the Ancestral Repertoire of Vertebrate IFN-Stimulated Genes. Journal of immunology (Baltimore, Md. : 1950). 192:4328-41
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
1 - 5 of 5
Show