Gene
cd83
- ID
- ZDB-GENE-060503-762
- Name
- CD83 molecule
- Symbol
- cd83 Nomenclature History
- Previous Names
-
- si:ch211-149p10.2
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Acts upstream of or within T cell activation involved in immune response and dendritic cell antigen processing and presentation. Located in cell surface. Part of IgM immunoglobulin complex. Is expressed in several structures, including digestive system; gill; heart; immune system; and integument. Orthologous to human CD83 (CD83 molecule).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cssl:d213 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Immunoglobulin domain subtype | Immunoglobulin-like beta-sandwich domain | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Immunoglobulin V-set domain |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A4JYN9 | InterPro | 211 | |||||||
| UniProtKB:A0A8M1NEQ7 | InterPro | 211 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-149P10 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-77N11 | ZFIN Curated Data | |
| Encodes | cDNA | cssl:d213 | Bushell et al., 2007 | |
| Encodes | cDNA | MGC:193677 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193691 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001098249 (1) | 1345 nt | ||
| Genomic | GenBank:AL929093 | 177248 nt | ||
| Polypeptide | UniProtKB:A0A8M1NEQ7 (1) | 211 aa |
- Hong, Y., Hu, C.B., Bai, J., Fan, D.D., Lin, A.F., Xiang, L.X., Shao, J.Z. (2023) Essential role of an ERV-derived Env38 protein in adaptive humoral immunity against an exogenous SVCV infection in a zebrafish model. PLoS pathogens. 19:e1011222e1011222
- Shao, T., Ji, J.F., Zheng, J.Y., Li, C., Zhu, L.Y., Fan, D.D., Lin, A.F., Xiang, L.X., Shao, J.Z. (2022) Zbtb46 Controls Dendritic Cell Activation by Reprogramming Epigenetic Regulation of cd80/86 and cd40 Costimulatory Signals in a Zebrafish Model. Journal of immunology (Baltimore, Md. : 1950). 208(12):2686-2701
- Lin, Z., Luo, M., Zhou, B., Liu, Y., Sun, H. (2021) CFTR regulates embryonic T lymphopoiesis via Wnt signaling in zebrafish. Immunology Letters. 234:47-53
- Kuil, L.E., Oosterhof, N., Ferrero, G., Mikulášová, T., Hason, M., Dekker, J., Rovira, M., van der Linde, H.C., van Strien, P.M., de Pater, E., Schaaf, G., Bindels, E.M., Wittamer, V., van Ham, T.J. (2020) Zebrafish macrophage developmental arrest underlies depletion of microglia and reveals Csf1r-independent metaphocytes. eLIFE. 9:
- Lin, X., Zhou, Q., Zhao, C., Lin, G., Xu, J., Wen, Z. (2019) An Ectoderm-Derived Myeloid-like Cell Population Functions as Antigen Transporters for Langerhans Cells in Zebrafish Epidermis. Developmental Cell. 49(4):605-617.e5
- Shao, T., Zhu, L.Y., Nie, L., Shi, W., Dong, W.R., Xiang, L.X., Shao, J.Z. (2015) Characterization of surface phenotypic molecules of teleost dendritic cells. Developmental and comparative immunology. 49:38-43
- García-Valtanen, P., Martinez-Lopez, A., Ortega-Villaizan, M., Perez, L., Coll, J.M., and Estepa, A. (2014) In addition to its antiviral and immunomodulatory properties, the zebrafish Beta-defensin 2 (zfBD2) is a potent viral DNA vaccine molecular adjuvant. Antiviral Research. 101:136-147
- Zhu, L.Y., Lin, A.F., Shao, T., Nie, L., Dong, W.R., Xiang, L.X., and Shao, J.Z. (2014) B cells in teleost fish act as pivotal initiating APCs in priming adaptive immunity: an evolutionary perspective on the origin of the B-1 cell subset and B7 molecules. Journal of immunology (Baltimore, Md. : 1950). 192(6):2699-2714
- Lin, A.F., Xiang, L.X., Wang, Q.L., Dong, W.R., Gong, Y.F., and Shao, J.Z. (2009) The DC-SIGN of Zebrafish: Insights into the Existence of a CD209 Homologue in a Lower Vertebrate and Its Involvement in Adaptive Immunity. Journal of immunology (Baltimore, Md. : 1950). 183(11):7398-7410
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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