Gene
sumf1
- ID
- ZDB-GENE-060421-3113
- Name
- sulfatase modifying factor 1
- Symbol
- sumf1 Nomenclature History
- Previous Names
-
- zgc:136465 (1)
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable formylglycine-generating oxidase activity. Acts upstream of or within several processes, including microglia development; regulation of cartilage development; and sulfolipid metabolic process. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in mucosulfatidosis. Orthologous to human SUMF1 (sulfatase modifying factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7154720 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from Fleming et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| mucosulfatidosis | Alliance | Multiple sulfatase deficiency | 272200 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | C-type lectin fold | Sulfatase Modifying Factor and Kinase | Sulfatase-modifying factor enzyme-like domain | Sulfatase-modifying factor enzyme superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:Q1RM47 | InterPro | 335 | ||||
| UniProtKB:F1QHA4 | InterPro | 370 | ||||
| UniProtKB:A0A8M1N8S9 | InterPro | 335 |
Interactions and Pathways
No data available
Plasmids
No data available