Gene
myl4
- ID
- ZDB-GENE-050626-112
- Name
- myosin, light chain 4, alkali; atrial, embryonic
- Symbol
- myl4 Nomenclature History
- Previous Names
-
- im:7136900
- zgc:114164
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity. Predicted to be part of myosin II complex. Is expressed in cephalic musculature; myotome; pectoral fin musculature; and somite. Human ortholog(s) of this gene implicated in cardiomyopathy and familial atrial fibrillation. Orthologous to human MYL4 (myosin light chain 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7136900 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Ghazizadeh et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| bw24 | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-myl4 | Ghazizadeh et al., 2019 | |
| CRISPR2-myl4 | Ghazizadeh et al., 2019 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ?Atrial fibrillation, familial, 18 | 617280 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Calmodulin/Myosin light chain/Troponin C-like | EF-hand domain | EF-hand domain pair |
|---|---|---|---|---|---|
| UniProtKB:Q4QRD2 | InterPro | 187 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(myh6:myl4,cryaa:mCherry) |
|
| 1 | Orr et al., 2016 | |
| Tg(myh6:myl4_E17K,cryaa:mCherry) |
|
| 1 | Orr et al., 2016 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-176F10 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7136900 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:114164 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001025183 (1) | 1221 nt | ||
| Genomic | GenBank:CU467632 (1) | 54849 nt | ||
| Polypeptide | UniProtKB:Q4QRD2 (1) | 187 aa |
- Cai, W., Wang, Y., Luo, Y., Gao, L., Zhang, J., Jiang, Z., Fan, X., Li, F., Xie, Y., Wu, X., Li, Y., Yuan, W. (2023) asb5a/asb5b Double Knockout Affects Zebrafish Cardiac Contractile Function. International Journal of Molecular Sciences. 24(22):
- Mao, K., Li, X., Chen, Z., Dong, X., Zhangsun, D., Zhu, X., Luo, S. (2022) α-Conotoxin TxIB Improved Behavioral Abnormality and Changed Gene Expression in Zebrafish (Danio rerio) Induced by Alcohol Withdrawal. Frontiers in pharmacology. 13:802917
- Luo, X., Chen, L., Zhang, Y., Liu, J., Xie, H. (2020) Developmental and cardiac toxicities of propofol in zebrafish larvae. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 237:108838
- Cho, H.J., Lee, J.G., Kim, J.H., Kim, S.Y., Huh, Y.H., Kim, H.J., Lee, K.S., Yu, K., Lee, J.S. (2019) Vascular defects of DYRK1A knockouts are ameliorated by modulating calcium signaling in zebrafish. Disease models & mechanisms. 12(5):
- Ghazizadeh, Z., Kiviniemi, T.O., Olafsson, S., Plotnick, D., Beerens, M., Zhang, K., Gillon, L., Steinbaugh, M., Barrera, V., Ho Sui, S., Werdich, A.A., Kapur, S., Eranti, A., Gunn, J., Jalkanen, J., Airaksinen, J., Kleber, A.G., Hollmén, M., MacRae, C.A. (2019) A Metastable Atrial State Underlies The Primary Genetic Substrate for MYL4 Mutation-Associated Atrial Fibrillation. Circulation. 141(4):301-312
- Garcia de la Serrana, D., Wreggelsworth, K., Johnston, I.A. (2018) Duplication of a Single myhz1.1 Gene Facilitated the Ability of Goldfish (Carassius auratus) to Alter Fast Muscle Contractile Properties With Seasonal Temperature Change. Frontiers in Physiology. 9:1724
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Sugden, W.W., Meissner, R., Aegerter-Wilmsen, T., Tsaryk, R., Leonard, E.V., Bussmann, J., Hamm, M.J., Herzog, W., Jin, Y., Jakobsson, L., Denz, C., Siekmann, A.F. (2017) Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues. Nature cell biology. 19(6):653-665
- Orr, N., Arnaout, R., Gula, L.J., Spears, D.A., Leong-Sit, P., Li, Q., Tarhuni, W., Reischauer, S., Chauhan, V.S., Borkovich, M., Uppal, S., Adler, A., Coughlin, S.R., Stainier, D.Y., Gollob, M.H. (2016) A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation. Nature communications. 7:11303
- Chen, Z., Huang, W., Dahme, T., Rottbauer, W., Ackerman, M.J., and Xu, X. (2008) Depletion of Zebrafish Essential and Regulatory Myosin Light Chains Reduces Cardiac Function Through Distinct Mechanisms. Cardiovascular research. 79(1):97-108
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