Gene
ercc5
- ID
- ZDB-GENE-050327-28
- Name
- excision repair cross-complementation group 5
- Symbol
- ercc5 Nomenclature History
- Previous Names
-
- zgc:110827
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable DNA endonuclease activity and single-stranded DNA binding activity. Predicted to be involved in nucleotide-excision repair and response to UV. Predicted to act upstream of or within DNA repair. Predicted to be located in chromosome. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in several diseases, including cerebrooculofacioskeletal syndrome 3; melanoma; respiratory system cancer (multiple); stomach cancer; and xeroderma pigmentosum group G. Orthologous to human ERCC5 (ERCC excision repair 5, endonuclease).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:110827 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| cerebrooculofacioskeletal syndrome 3 | Alliance | Cerebrooculofacioskeletal syndrome 3 | 616570 |
| xeroderma pigmentosum group G | Alliance | Xeroderma pigmentosum, group G | 278780 |
| xeroderma pigmentosum group G | Alliance | Xeroderma pigmentosum, group G/Cockayne syndrome | 278780 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR008918 | Helix-hairpin-helix motif, class 2 |
| Conserved_site | IPR019974 | XPG conserved site |
| Domain | IPR006085 | XPG, N-terminal |
| Domain | IPR006086 | XPG-I domain |
| Family | IPR001044 | XPG/Rad2 endonuclease, eukaryotes |
| Family | IPR006084 | XPG/Rad2 endonuclease |
| Homologous_superfamily | IPR029060 | PIN-like domain superfamily |
| Homologous_superfamily | IPR036279 | 5'-3' exonuclease, C-terminal domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | 5'-3' exonuclease, C-terminal domain superfamily | Helix-hairpin-helix motif, class 2 | PIN-like domain superfamily | XPG conserved site | XPG-I domain | XPG, N-terminal | XPG/Rad2 endonuclease | XPG/Rad2 endonuclease, eukaryotes |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1QJS3 | InterPro | 1010 |
Interactions and Pathways
No data available
Plasmids
No data available