Gene
itga6a
- ID
- ZDB-GENE-050309-23
- Name
- integrin, alpha 6a
- Symbol
- itga6a Nomenclature History
- Previous Names
-
- itga6
- fb80g02
- im:6897425
- si:dkey-32o22.1
- wu:fb80g02
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable signaling receptor activity. Acts upstream of or within skeletal muscle tissue development. Predicted to be located in membrane. Predicted to be part of integrin alpha6-beta1 complex and integrin alpha6-beta4 complex. Predicted to be active in cell surface. Is expressed in several structures, including axial chorda mesoderm; hypodermis; retina; solid lens vesicle; and trunk. Human ortholog(s) of this gene implicated in junctional epidermolysis bullosa and junctional epidermolysis bullosa with pyloric atresia. Orthologous to human ITGA6 (integrin subunit alpha 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6897425 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Goody et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Epidermolysis bullosa, junctional 6, with pyloric atresia | 619817 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018184 | Integrin alpha chain, C-terminal cytoplasmic region, conserved site |
| Domain | IPR013649 | Integrin alpha, first immunoglubulin-like domain |
| Domain | IPR048285 | Integrin alpha, second immunoglobulin-like domain |
| Domain | IPR048286 | Integrin alpha, third immunoglobulin-like domain |
| Family | IPR000413 | Integrin alpha chain |
| Homologous_superfamily | IPR028994 | Integrin alpha, N-terminal |
| Homologous_superfamily | IPR032695 | Integrin domain superfamily |
| Repeat | IPR013517 | FG-GAP repeat |
| Repeat | IPR013519 | Integrin alpha beta-propellor |
Domain Details Per Protein
| Protein | Additional Resources | Length | FG-GAP repeat | Integrin alpha beta-propellor | Integrin alpha chain | Integrin alpha chain, C-terminal cytoplasmic region, conserved site | Integrin alpha, first immunoglubulin-like domain | Integrin alpha, N-terminal | Integrin alpha, second immunoglobulin-like domain | Integrin alpha, third immunoglobulin-like domain | Integrin domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A8WHQ7 | InterPro | 1071 | |||||||||
| UniProtKB:A8WHQ8 | InterPro | 1092 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cu469503.1-201
(1)
|
Ensembl | 1,274 nt | ||
| mRNA |
itga6a-201
(1)
|
Ensembl | 3,231 nt | ||
| mRNA |
itga6a-202
(1)
|
Ensembl | 4,057 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-itga6a | polyclonal | Guinea pig |
|
1 |
Plasmids
No data available