Gene
alx4b
- ID
- ZDB-GENE-050208-140
- Name
- ALX homeobox 4b
- Symbol
- alx4b Nomenclature History
- Previous Names
-
- im:7142878
- si:ch73-220n21.1
- zgc:162606 (1)
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable DNA binding activity. Predicted to be located in nucleus. Is expressed in several structures, including brain; eye; optic vesicle; pharyngeal arch; and swim bladder bud. Human ortholog(s) of this gene implicated in craniosynostosis; frontonasal dysplasia 2; gastrointestinal system cancer (multiple); lung cancer (multiple); and parietal foramina. Orthologous to human ALX4 (ALX homeobox 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7142878 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| co3001 | Allele with one deletion | Exon 2 | Unknown | CRISPR | |
| j327 | Allele with one deletion | Exon 1 | Unknown | CRISPR | |
| la027951Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la027952Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa36701 | Allele with one point mutation | Unknown | Unknown | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-alx4b | Mitchell et al., 2021 | |
| CRISPR2-alx4b | Jang et al., 2021 | |
| CRISPR3-alx4b | Jang et al., 2021 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| frontonasal dysplasia 2 | Alliance | Frontonasal dysplasia 2 | 613451 |
| parietal foramina | Alliance | Parietal foramina 2 | 609597 |
| {Craniosynostosis 5, susceptibility to} | 615529 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003654 | OAR domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | OAR domain |
|---|---|---|---|
| UniProtKB:A0A2R8RTN2 | InterPro | 259 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-220N21 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-127O16 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7142878 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:162606 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001089357 (1) | 2028 nt | ||
| Genomic | GenBank:CU929277 (2) | 100482 nt | ||
| Polypeptide | UniProtKB:A0A2R8RTN2 (1) | 259 aa |
- Jang, H.S., Chen, Y., Ge, J., Wilkening, A.N., Hou, Y., Lee, H.J., Choi, Y.R., Lowdon, R.F., Xing, X., Li, D., Kaufman, C.K., Johnson, S.L., Wang, T. (2021) Epigenetic dynamics shaping melanophore and iridophore cell fate in zebrafish. Genome biology. 22:282
- Mitchell, J.M., Sucharov, J., Pulvino, A.T., Brooks, E.P., Gillen, A.E., Nichols, J.T. (2021) The alx3 gene shapes the zebrafish neurocranium by regulating frontonasal neural crest cell differentiation timing. Development (Cambridge, England). 148(7):
- Pini, J., Kueper, J., Hu, Y.D., Kawasaki, K., Yeung, P., Tsimbal, C., Yoon, B., Carmichael, N., Maas, R.L., Cotney, J., Grinblat, Y., Liao, E.C. (2020) ALX1-related frontonasal dysplasia results from defective neural crest cell development and migration. EMBO Molecular Medicine. 12(10):e12013
- Saunders, L.M., Mishra, A.K., Aman, A.J., Lewis, V.M., Toomey, M.B., Packer, J.S., Qiu, X., McFaline-Figueroa, J.L., Corbo, J.C., Trapnell, C., Parichy, D.M. (2019) Thyroid hormone regulates distinct paths to maturation in pigment cell lineages. eLIFE. 8:
- Sharma, P., MacLean, A.L., Meinecke, L., Clouthier, D., Nie, Q., Schilling, T.F. (2018) Transcriptomics reveals complex kinetics of dorsal-ventral patterning gene expression in the mandibular arch. Genesis (New York, N.Y. : 2000). 57(1):e23275
- Liu, C., Hu, J., Qu, C., Wang, L., Huang, G., Niu, P., Zhong, Z., Hong, F., Wang, G., Postlethwait, J.H., Wang, H. (2015) Molecular evolution and functional divergence of zebrafish (Danio rerio) cryptochrome genes. Scientific Reports. 5:8113
- Lours-Calet, C., Alvares, L.E., El-Hanfy, A.S., Gandesha, S., Walters, E.H., Sobreira, D.R., Wotton, K.R., Jorge, E.C., Lawson, J.A., Kelsey Lewis, A., Tada, M., Sharpe, C., Kardon, G., Dietrich, S. (2014) Evolutionarily conserved morphogenetic movements at the vertebrate head-trunk interface coordinate the transport and assembly of hypopharyngeal structures. Developmental Biology. 390:231-46
- Dee, C.T., Szymoniuk, C.R., Mills, P.E., and Takahashi, T. (2013) Defective Neural Crest Migration Revealed by a Zebrafish model of Alx1-Related Frontonasal Dysplasia. Human molecular genetics. 22(2):239-251
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- McGonnell, I.M., Graham, A., Richardson, J., Fish, J.L., Depew, M.J., Dee, C.T., Holland, P.W., and Takahashi, T. (2011) Evolution of the Alx homeobox gene family: parallel retention and independent loss of the vertebrate Alx3 gene. Evolution & development. 13(4):353-351
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