Gene
kif3b
- ID
- ZDB-GENE-050119-3
- Name
- kinesin family member 3B
- Symbol
- kif3b Nomenclature History
- Previous Names
-
- zgc:165446 (1)
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Involved in cilium assembly and photoreceptor cell development. Acts upstream of or within several processes, including nose development; photoreceptor cell outer segment organization; and sensory system development. Part of kinesin complex. Is expressed in forerunner cell group and retina. Human ortholog(s) of this gene implicated in retinitis pigmentosa 89. Orthologous to human KIF3B (kinesin family member 3B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| jj203 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa5805 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa6722 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa39397 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-kif3b | Lam et al., 2021 | |
| MO1-kif3b | N/A | Insinna et al., 2009 |
| MO2-kif3b | N/A | Insinna et al., 2009 |
| MO3-kif3b | N/A | (2) |
| MO4-kif3b | N/A | Zhao et al., 2012 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| retinitis pigmentosa 89 | Alliance | Retinitis pigmentosa 89 | 618955 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019821 | Kinesin motor domain, conserved site |
| Domain | IPR001752 | Kinesin motor domain |
| Family | IPR027640 | Kinesin-like protein |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Kinesin-like protein | Kinesin motor domain | Kinesin motor domain, conserved site | Kinesin motor domain superfamily | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|
| UniProtKB:F1QN54 | InterPro | 775 | |||||
| UniProtKB:A0A8M2BLD4 | InterPro | 774 | |||||
| UniProtKB:A0AB32TH43 | InterPro | 775 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-254L12 | ZFIN Curated Data | |
| Encodes | STS | zf37276-448f17.q1k | ||
| Encodes | cDNA | MGC:165446 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001100145 (1) | 2723 nt | ||
| Genomic | GenBank:FO904971 (1) | 179681 nt | ||
| Polypeptide | UniProtKB:A0AB32TH43 (1) | 775 aa |
- Sun, Y., Chen, Z., Jin, M., Xie, H., Zhao, C. (2024) Ciliary length regulation by intraflagellar transport in zebrafish. eLIFE. 13:
- Lam, W.Y., Tang, C.S., So, M.T., Yue, H., Hsu, J.S., Chung, P.H., Nicholls, J.M., Yeung, F., Lee, C.D., Ngo, D.N., Nguyen, P.A.H., Mitchison, H.M., Jenkins, D., O'Callaghan, C., Garcia-Barceló, M.M., Lee, S.L., Sham, P.C., Lui, V.C., Tam, P.K. (2021) Identification of a wide spectrum of ciliary gene mutations in nonsyndromic biliary atresia patients implicates ciliary dysfunction as a novel disease mechanism. EBioMedicine. 71:103530
- Cogné, B., Latypova, X., Senaratne, L.D.S., Martin, L., Koboldt, D.C., Kellaris, G., Fievet, L., Le Meur, G., Caldari, D., Debray, D., Nizon, M., Frengen, E., Bowne, S.J., 99 Lives Consortium, Cadena, E.L., Daiger, S.P., Bujakowska, K.M., Pierce, E.A., Gorin, M., Katsanis, N., Bézieau, S., Petersen-Jones, S.M., Occelli, L.M., Lyons, L.A., Legeai-Mallet, L., Sullivan, L.S., Davis, E.E., Isidor, B. (2020) Mutations in the Kinesin-2 Motor KIF3B Cause an Autosomal-Dominant Ciliopathy. American journal of human genetics. 106(6):893-904
- Nishiwaki, Y., Masai, I. (2020) β-SNAP activity in the outer segment growth period is critical for preventing BNip1-dependent apoptosis in zebrafish photoreceptors. Scientific Reports. 10:17379
- Zhang, X., Jia, S., Chen, Z., Chong, Y.L., Xie, H., Feng, D., Wu, X., Song, D.Z., Roy, S., Zhao, C. (2018) Cilia-driven cerebrospinal fluid flow directs expression of urotensin neuropeptides to straighten the vertebrate body axis. Nature Genetics. 50(12):1666-1673
- Feng, D., Chen, Z., Yang, K., Miao, S., Xu, B., Kang, Y., Xie, H., Zhao, C. (2017) The cytoplasmic tail of rhodopsin triggers rapid rod degeneration in kinesin-2 mutants. The Journal of biological chemistry. 292(42):17375-17386
- Shim, H., Kim, J.H., Kim, C.Y., Hwang, S., Kim, H., Yang, S., Lee, J.E., Lee, I. (2016) Function-driven discovery of disease genes in zebrafish using an integrated genomics big data resource. Nucleic acids research. 44:9611-9623
- Neugebauer, J.M., Cadwallader, A.B., Amack, J.D., Bisgrove, B.W., and Yost, H.J. (2013) Differential roles for 3-OSTs in the regulation of cilia length and motility. Development (Cambridge, England). 140(18):3892-3902
- Zhao, C., Omori, Y., Brodowska, K., Kovach, P., and Malicki, J. (2012) Kinesin-2 family in vertebrate ciliogenesis. Proceedings of the National Academy of Sciences of the United States of America. 109(7):2388-2393
- Insinna, C., Humby, M., Sedmak, T., Wolfrum, U., and Besharse, J.C. (2009) Different roles for KIF17 and kinesin II in photoreceptor development and maintenance. Developmental Dynamics : an official publication of the American Association of Anatomists. 238(9):2211-2222
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