Gene
pus1
- ID
- ZDB-GENE-041212-26
- Name
- pseudouridine synthase 1
- Symbol
- pus1 Nomenclature History
- Previous Names
-
- wu:fb98h11
- zgc:103516
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable pseudouridine synthase activity. Predicted to be involved in mRNA pseudouridine synthesis and tRNA pseudouridine synthesis. Predicted to act upstream of or within pseudouridine synthesis and tRNA processing. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in myopathy, lactic acidosis, and sideroblastic anemia 1. Orthologous to human PUS1 (pseudouridine synthase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Mishima et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| myopathy, lactic acidosis, and sideroblastic anemia 1 | Alliance | Myopathy, lactic acidosis, and sideroblastic anemia 1 | 600462 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR020097 | Pseudouridine synthase I, TruA, alpha/beta domain |
| Family | IPR001406 | Pseudouridine synthase I, TruA |
| Family | IPR041708 | Pseudouridine synthase PUS1/ PUS2-like |
| Homologous_superfamily | IPR020094 | Pseudouridine synthase TruA/RsuA/RluB/E/F, N-terminal |
| Homologous_superfamily | IPR020095 | Pseudouridine synthase I, TruA, C-terminal |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Pseudouridine synthase, catalytic domain superfamily | Pseudouridine synthase I, TruA | Pseudouridine synthase I, TruA, alpha/beta domain | Pseudouridine synthase I, TruA, C-terminal | Pseudouridine synthase PUS1/ PUS2-like | Pseudouridine synthase TruA/RsuA/RluB/E/F, N-terminal |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1QWW1 | InterPro | 412 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-11O18 | ZFIN Curated Data | |
| Encodes | EST | fb98h11 | ||
| Encodes | EST | IMAGE:5411761 | Thisse et al., 2004 | |
| Encodes | EST | IMAGE:7161210 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:103516 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001008603 (1) | 1538 nt | ||
| Genomic | GenBank:CR450803 (1) | 97834 nt | ||
| Polypeptide | UniProtKB:F1QWW1 (1) | 412 aa |
- Mishima, Y., Tomari, Y. (2016) Codon Usage and 3' UTR Length Determine Maternal mRNA Stability in Zebrafish. Molecular Cell. 61:874-885
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Liu, R., Li, M., Li, Z., Hong, N., Xu, H., Hong, Y. (2015) Medaka Oct4 is Essential for Pluripotency in Blastula Formation and ES Cell Derivation. Stem cell reviews. 11(1):11-23
- Briolat, V., Jouneau, L., Carvalho, R., Palha, N., Langevin, C., Herbomel, P., Schwartz, O., Spaink, H.P., Levraud, J.P., Boudinot, P. (2014) Contrasted Innate Responses to Two Viruses in Zebrafish: Insights into the Ancestral Repertoire of Vertebrate IFN-Stimulated Genes. Journal of immunology (Baltimore, Md. : 1950). 192:4328-41
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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