Gene
pcdh2ab7
- ID
- ZDB-GENE-041118-6
- Name
- protocadherin 2 alpha b 7
- Symbol
- pcdh2ab7 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Ambiguous Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity. Predicted to act upstream of or within homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to be located in plasma membrane. Orthologous to several human genes including PCDHA1 (protocadherin alpha 1); PCDHA10 (protocadherin alpha 10); and PCDHA13 (protocadherin alpha 13).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Tada et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa9977 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-pcdh2a | N/A | Emond et al., 2008 |
| MO2-pcdh2a | N/A | Emond et al., 2008 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cadherin conserved site | Cadherin, C-terminal catenin-binding domain | Cadherin, cytoplasmic C-terminal domain | Cadherin-like | Cadherin-like superfamily | Cadherin, N-terminal | Protocadherin/Cadherin-related Cell Adhesion |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q60I70 | InterPro | 939 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pcdh2ab8-201
(1)
|
Ensembl | 3,361 nt | ||
| mRNA |
pcdh2ab9-202
(1)
|
Ensembl | 1,203 nt | ||
| mRNA |
pcdh2ab9-203
(1)
|
Ensembl | 3,343 nt | ||
| mRNA |
pcdh2ab9-204
(1)
|
Ensembl | 3,355 nt | ||
| mRNA |
pcdh2ab9-205
(1)
|
Ensembl | 3,352 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-262J3 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-115D7 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001009594 (1) | 3366 nt | ||
| Genomic | GenBank:CR847851 | 161657 nt | ||
| Polypeptide | UniProtKB:Q60I70 (1) | 939 aa |
No data available
- Tan, Y.P., Li, S., Jiang, X.J., Loh, W., Foo, Y.K., Loh, C.B., Xu, Q., Yuen, W.H., Jones, M., Fu, J., Venkatesh, B., and Yu, W.P. (2010) Regulation of protocadherin gene expression by multiple neuron-restrictive silencer elements scattered in the gene cluster. Nucleic acids research. 38(15):4985-4997
- Emond, M.R., and Jontes, J.D. (2008) Inhibition of protocadherin-alpha function results in neuronal death in the developing zebrafish. Developmental Biology. 321(1):175-187
- Tada, M.N., Senzaki, K., Tai, Y., Morishita, H., Tanaka, Y.Z., Murata, Y., Ishii, Y., Asakawa, S., Shimizu, N., Sugino, H., and Yagi, T. (2004) Genomic organization and transcripts of the zebrafish Protocadherin genes. Gene. 340(2):197-211
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