Gene
egr3
- ID
- ZDB-GENE-040718-394
- Name
- early growth response 3
- Symbol
- egr3 Nomenclature History
- Previous Names
-
- zgc:92020
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in hindbrain; myeloid cell; optic tectum; and telencephalon. Orthologous to human EGR3 (early growth response 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92020 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from da Silva et al., 2024
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| bns522 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| bns576Pt | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| bns577 | Allele with one deletion | Exon 2 | Unknown | CRISPR | |
| bns661Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| sa7160 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa21390 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 6 of 6
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-egr3 | Kenyon et al., 2017 | |
| CRISPR2-egr3 | Kenyon et al., 2017 | |
| CRISPR3-egr3 | Kenyon et al., 2017 | |
| CRISPR4-egr3 | (2) | |
| CRISPR5-egr3 | (2) | |
| CRISPR6-egr3 | (2) | |
| CRISPR7-egr3 | da Silva et al., 2024 | |
| CRISPR8-egr3 | da Silva et al., 2024 |
1 - 8 of 8
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Early growth response, N-terminal | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|---|
| UniProtKB:Q6DG27 | InterPro | 422 | |||
| UniProtKB:A0AB32U040 | InterPro | 386 |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-6L19 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-278H8 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:92020 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191185 | ZFIN Curated Data |
1 - 4 of 4
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002647 (1) | 3280 nt | ||
| Genomic | GenBank:CU855695 (2) | 58364 nt | ||
| Polypeptide | UniProtKB:Q6DG27 (1) | 422 aa |
- da Silva, A.R., Gunawan, F., Boezio, G.L.M., Faure, E., Théron, A., Avierinos, J.F., Lim, S., Jha, S.G., Ramadass, R., Guenther, S., Looso, M., Zaffran, S., Juan, T., Stainier, D.Y.R. (2024) egr3 is a mechanosensitive transcription factor gene required for cardiac valve morphogenesis. Science advances. 10:eadl0633
- Wang, Z.Y., Mehra, A., Wang, Q.C., Gupta, S., Ribeiro da Silva, A., Juan, T., Günther, S., Looso, M., Detleffsen, J., Stainier, D.Y.R., Marín-Juez, R. (2024) flt1 inactivation promotes zebrafish cardiac regeneration by enhancing endothelial activity and limiting the fibrotic response. Development (Cambridge, England). 151(23):
- Turner, K.J., Hawkins, T.A., Henriques, P.M., Valdivia, L.E., Bianco, I.H., Wilson, S.W., Folgueira, M. (2022) A Structural Atlas of the Developing Zebrafish Telencephalon Based on Spatially-Restricted Transgene Expression. Frontiers in Neuroanatomy. 16:840924
- Pohl, J., Golovko, O., Carlsson, G., Örn, S., Schmitz, M., Ahi, E.P. (2021) Gene co-expression network analysis reveals mechanisms underlying ozone-induced carbamazepine toxicity in zebrafish (Danio rerio) embryos. Chemosphere. 276:130282
- Jung, I.H., Jung, D.E., Chung, Y.Y., Kim, K.S., Park, S.W. (2019) Iroquois Homeobox 1 Acts as a True Tumor Suppressor in Multiple Organs by Regulating Cell Cycle Progression. Neoplasia (New York, N.Y.). 21:1003-1014
- Fish, J.E., Cantu Gutierrez, M., Dang, L.T., Khyzha, N., Chen, Z., Veitch, S., Cheng, H.S., Khor, M., Antounians, L., Njock, M.S., Boudreau, E., Herman, A.M., Rhyner, A.M., Ruiz, O.E., Eisenhoffer, G.T., Medina-Rivera, A., Wilson, M.D., Wythe, J.D. (2017) Dynamic regulation of VEGF-inducible genes by an ERK/ERG/p300 transcriptional network. Development (Cambridge, England). 144:2428-2444
- Kenyon, A., Gavriouchkina, D., Zorman, J., Napolitani, G., Cerundolo, V., Sauka-Spengler, T. (2017) Active nuclear transcriptome analysis reveals inflammasome-dependent mechanism for early neutrophil response to Mycobacterium marinum. Scientific Reports. 7:6505
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Yang, S., Marín-Juez, R., Meijer, A.H., Spaink, H.P. (2015) Common and specific downstream signaling targets controlled by Tlr2 and Tlr5 innate immune signaling in zebrafish. BMC Genomics. 16:547
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
1 - 10 of 10
Show