Gene
mymk
- ID
- ZDB-GENE-040625-66
- Name
- myomaker, myoblast fusion factor
- Symbol
- mymk Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Involved in myoblast fusion and regulation of skeletal muscle fiber development. Acts upstream of or within skeletal muscle tissue growth. Located in membrane. Is expressed in muscle; post-vent region; and trunk. Used to study Carey-Fineman-Ziter syndrome. Human ortholog(s) of this gene implicated in Carey-Fineman-Ziter syndrome 1. Orthologous to human MYMK (myomaker, myoblast fusion factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 20 figures from 8 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| cl201 | Allele with one insertion | Exon 3 | Frameshift | CRISPR | |
| mb13 | Allele with one deletion | Unknown | Frameshift, Premature Stop | CRISPR | |
| mb14 | Allele with one delins | Unknown | Frameshift, Premature Stop | CRISPR | |
| mb15 | Allele with one delins | Unknown | Frameshift, Premature Stop | CRISPR | |
| oz17 | Allele with one deletion | Exon 3 | Frameshift | CRISPR | |
| oz25 | Allele with one deletion | Exon 3 | Frameshift | CRISPR | |
| sq35 | Allele with one deletion | Exon 1 | Premature Stop | CRISPR | |
| sq36 | Allele with one delins | Unknown | Premature Stop | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-mymk | (2) | |
| CRISPR2-mymk | (2) | |
| CRISPR3-mymk | (2) | |
| CRISPR4-mymk | (2) | |
| CRISPR5-mymk | (6) | |
| MO1-mymk | N/A | (3) |
| MO2-mymk | N/A | (3) |
| MO3-mymk | N/A | Di Gioia et al., 2017 |
| MO4-mymk | N/A | Di Gioia et al., 2017 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Carey-Fineman-Ziter syndrome 1 | Alliance | Carey-Fineman-Ziter syndrome | 254940 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Carey-Fineman-Ziter syndrome | mymkcl201/cl201 (AB) | standard conditions | Di Gioia et al., 2017 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR021910 | NGX6/PGAP6/MYMK |
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Domain Details Per Protein
| Protein | Additional Resources | Length | NGX6/PGAP6/MYMK |
|---|---|---|---|
| UniProtKB:Q6IQ69 | InterPro | 220 | |
| UniProtKB:A0A8M6Z0J1 | InterPro | 258 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-272F14 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-191H14 | ZFIN Curated Data | |
| Contained in | BAC | RP71-39F17 | ZFIN Curated Data | |
| Encodes | EST | fb30h02 | ||
| Encodes | cDNA | MGC:86927 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | GenBank:BC071541 (1) | 2074 nt | ||
| Genomic | GenBank:BX927256 | 51445 nt | ||
| Polypeptide | UniProtKB:A0A8M6Z0J1 (1) | 258 aa |
- Yong, P., Zhang, Z., Du, S. (2024) Ectopic expression of Myomaker and Myomixer in slow muscle cells induces slow muscle fusion and myofiber death. Journal of genetics and genomics = Yi chuan xue bao. 51(11):1187-1203
- Luo, Z., Shi, J., Pandey, P., Ruan, Z.R., Sevdali, M., Bu, Y., Lu, Y., Du, S., Chen, E.H. (2022) The cellular architecture and molecular determinants of the zebrafish fusogenic synapse. Developmental Cell. 57(13):1582-1597.e6
- Mendieta-Serrano, M.A., Dhar, S., Ng, B.H., Narayanan, R., Lee, J.J.Y., Ong, H.T., Toh, P.J.Y., Röllin, A., Roy, S., Saunders, T.E. (2022) Slow muscles guide fast myocyte fusion to ensure robust myotome formation despite the high spatiotemporal stochasticity of fusion events. Developmental Cell. 57(17):2095-2110.e5
- Ganassi, M., Badodi, S., Wanders, K., Zammit, P.S., Hughes, S.M. (2020) Myogenin is an essential regulator of adult myofibre growth and muscle stem cell homeostasis. eLIFE. 9:
- Hromowyk, K.J., Talbot, J.C., Martin, B.L., Janssen, P.M.L., Amacher, S.L. (2020) Cell fusion is differentially regulated in zebrafish post-embryonic slow and fast muscle. Developmental Biology. 462(1):85-100
- Arribat, Y., Grepper, D., Lagarrigue, S., Richard, J., Gachet, M., Gut, P., Amati, F. (2019) Mitochondria in Embryogenesis: An Organellogenesis Perspective. Frontiers in cell and developmental biology. 7:282
- Ganassi, M., Badodi, S., Ortuste Quiroga, H.P., Zammit, P.S., Hinits, Y., Hughes, S.M. (2018) Myogenin promotes myocyte fusion to balance fibre number and size. Nature communications. 9:4232
- Shi, J., Cai, M., Si, Y., Zhang, J., Du, S. (2018) Knockout of myomaker results in defective myoblast fusion, reduced muscle growth and increased adipocyte infiltration in zebrafish skeletal muscle. Human molecular genetics. 27(20):3542-3554
- Si, Y., Wen, H., Du, S. (2018) Genetic Mutations in jamb, jamc, and myomaker Revealed Different Roles on Myoblast Fusion and Muscle Growth. Marine biotechnology (New York, N.Y.). 21(1):111-123
- Di Gioia, S.A., Connors, S., Matsunami, N., Cannavino, J., Rose, M.F., Gilette, N.M., Artoni, P., de Macena Sobreira, N.L., Chan, W.M., Webb, B.D., Robson, C.D., Cheng, L., Van Ryzin, C., Ramirez-Martinez, A., Mohassel, P., Leppert, M., Scholand, M.B., Grunseich, C., Ferreira, C.R., Hartman, T., Hayes, I.M., Morgan, T., Markie, D.M., Fagiolini, M., Swift, A., Chines, P.S., Speck-Martins, C.E., Collins, F.S., Jabs, E.W., Bönnemann, C.G., Olson, E.N., Carey, J.C., Robertson, S.P., Manoli, I., Engle, E.C. (2017) A defect in myoblast fusion underlies Carey-Fineman-Ziter syndrome. Nature communications. 8:16077
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