Gene
edem1
- ID
- ZDB-GENE-040426-808
- Name
- ER degradation enhancer, mannosidase alpha-like 1
- Symbol
- edem1 Nomenclature History
- Previous Names
-
- zgc:55816 (1)
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity and mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Predicted to be involved in endoplasmic reticulum unfolded protein response; mannoprotein catabolic process; and ubiquitin-dependent glycoprotein ERAD pathway. Predicted to act upstream of or within carbohydrate metabolic process; endoplasmic reticulum mannose trimming; and mannose trimming involved in glycoprotein ERAD pathway. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Is expressed in anterior axial hypoblast; hatching gland; head; liver; and polster. Orthologous to human EDEM1 (ER degradation enhancing alpha-mannosidase like protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 19 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55816 (4 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la025585Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa7046 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa7587 | Allele with one point mutation | Unknown | Missense | ENU | |
| sa31536 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa45265 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | ER degradation-enhancing alpha-mannosidase-like protein 1/2/3 | Glycoside hydrolase family 47 | Seven-hairpin glycosidases | Six-hairpin glycosidase-like superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:E9QJF1 | InterPro | 628 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-361P23 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-20F24 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:55816 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192795 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_201189 (1) | 3388 nt | ||
| Genomic | GenBank:BX950172 (1) | 231139 nt | ||
| Polypeptide | UniProtKB:E9QJF1 (1) | 628 aa |
- Li, Q., Pei, R., Chen, E., Zheng, F., Zhang, Y., Meng, S. (2024) Efficacy of Jiuzao polysaccharides in ameliorating alcoholic fatty liver disease and modulating gut microbiota. Heliyon. 10:e26167e26167
- Park, K.H., Makki, H.M.M., Kim, S.H., Chung, H.J., Jung, J. (2023) Narirutin ameliorates alcohol-induced liver injury by targeting MAPK14 in zebrafish larvae. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 166:115350115350
- Ritter, D.J., Choudhary, D., Unlu, G., Knapik, E.W. (2023) Rgp1 contributes to craniofacial cartilage development and Rab8a-mediated collagen II secretion. Frontiers in endocrinology. 14:11204201120420
- Elbialy, A., Sulidan, K., Bhuiyan, A., Igarashi, Y., Yoshitake, K., Yamanouchi, D., Kang, J., Asakawa, S., Watabe, S., Kinoshita, S. (2022) Induction of endoplasmic reticulum stress markers in an acromegaly model. Journal of cellular biochemistry. 123(9):1411-1421
- Ellis, J.L., Evason, K.J., Zhang, C., Fourman, M.N., Liu, J., Ninov, N., Delous, M., Vanhollebeke, B., Fiddes, I., Otis, J.P., Houvras, Y., Farber, S.A., Xu, X., Lin, X., Stainier, D.Y.R., Yin, C. (2022) A missense mutation in the proprotein convertase gene furinb causes hepatic cystogenesis during liver development in zebrafish. Hepatology communications. 6(11):3083-3097
- Sarkar, H., Toms, M., Moosajee, M. (2021) Involvement of Oxidative and Endoplasmic Reticulum Stress in RDH12-Related Retinopathies. International Journal of Molecular Sciences. 22(16):
- Zhang, L., Kim, S.H., Park, K.H., Townsend, D., Tew, K.D. (2021) Glutathione S-Transferase P Influences Redox Homeostasis and Response to Drugs that Induce the Unfolded Protein Response in Zebrafish. The Journal of pharmacology and experimental therapeutics. 377(1):121-132
- Delaney, P., Ramdas Nair, A., Palmer, C., Khan, N., Sadler, K.C. (2020) Arsenic induced redox imbalance triggers the unfolded protein response in the liver of zebrafish. Toxicology and applied pharmacology. 409:115307
- Liu, Y.S., Yuan, M.H., Zhang, C.Y., Liu, H.M., Liu, J.R., Wei, A.L., Ye, Q., Zeng, B., Li, M.F., Guo, Y.P., Guo, L. (2020) Puerariae Lobatae radix flavonoids and puerarin alleviate alcoholic liver injury in zebrafish by regulating alcohol and lipid metabolism. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 134:111121
- Yang, B., Maddison, L.A., Zaborska, K.E., Dai, C., Yin, L., Tang, Z., Zang, L., Jacobson, D.A., Powers, A.C., Chen, W. (2020) RIPK3-mediated inflammation is a conserved β cell response to ER stress. Science advances. 6(51):
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