Gene
rbm14b
- ID
- ZDB-GENE-040426-2455
- Name
- RNA binding motif protein 14b
- Symbol
- rbm14b Nomenclature History
- Previous Names
-
- zgc:85696
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable RNA binding activity and zinc ion binding activity. Acts upstream of with a negative effect on BMP signaling pathway. Predicted to be active in nucleolus. Orthologous to several human genes including RBM14 (RNA binding motif protein 14).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Xiao et al., 2019
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-rbm14b | N/A | (2) |
| MO2-rbm14b | N/A | Yu et al., 2024 |
| MO3-rbm14b | N/A | Xiao et al., 2022 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Eukaryotic RNA-binding | Nucleotide-binding alpha-beta plait domain superfamily | RBM14, RNA recognition motif 1 | RNA-binding domain superfamily | RNA recognition motif domain | RNA recognition motif domain, eukaryotes | RRM MRD1 RNA Processing and Ribosome Biogenesis | Zinc finger, CCHC-type | Zinc finger, CCHC-type superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1QG19 | InterPro | ||||||||||
| UniProtKB:A0A8M9Q1B8 | InterPro | 560 | |||||||||
| UniProtKB:A0A0R4IJ04 | InterPro | 556 | |||||||||
| UniProtKB:A0A8M9Q7N4 | InterPro | 560 | |||||||||
| UniProtKB:Q6NV05 | InterPro | 556 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
rbm14b-201
(1)
|
Ensembl | 2,257 nt | ||
| mRNA |
rbm14b-202
(1)
|
Ensembl | 2,257 nt | ||
| mRNA |
rbm14b-203
(1)
|
Ensembl | 9,621 nt | ||
| mRNA |
rbm14b-204
(1)
|
Ensembl | 3,016 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-258D20 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-87C11 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:65889 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:85696 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174014 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212808 (1) | 3102 nt | ||
| Genomic | GenBank:AL808019 (1) | 159698 nt | ||
| Polypeptide | UniProtKB:A0A8M9Q1B8 (1) | 560 aa |
- Yu, T., Chen, M., Wen, J., Liu, J., Li, K., Jin, L., Yue, J., Yang, Z., Xi, J. (2024) The effects of all-trans retinoic acid on prednisolone-induced osteoporosis in zebrafish larvae. Bone. 189:117261
- Xiao, Y., Chen, J., Yang, S., Sun, H., Xie, L., Li, J., Jing, N., Zhu, X. (2022) Maternal mRNA deadenylation and allocation via Rbm14 condensates facilitate vertebrate blastula development. The EMBO journal. 42(3):e111364
- Xiao, Y., Chen, J., Wan, Y., Gao, Q., Jing, N., Zheng, Y., Zhu, X. (2019) Regulation of zebrafish dorsoventral patterning by phase separation of RNA-binding protein Rbm14. Cell discovery. 5:37
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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