ZFIN is now using GRCz12tu for Genomic Data
Gene
rad51
- ID
- ZDB-GENE-040426-2286
- Name
- RAD51 recombinase
- Symbol
- rad51 Nomenclature History
- Previous Names
-
- wu:fb38e12
- zgc:77754
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable DNA binding activity and catalytic activity, acting on DNA. Acts upstream of or within several processes, including hematopoietic stem cell proliferation; response to cadmium ion; and response to methylmercury. Predicted to be located in chromosome and nucleus. Predicted to be active in condensed nuclear chromosome. Is expressed in brain; gill; liver; musculature system; and testis. Used to study Fanconi anemia. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group R; breast cancer; congenital mirror movement disorder; and ovarian cancer. Orthologous to human RAD51 (RAD51 recombinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77754 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| breast cancer | Alliance | {Breast cancer, susceptibility to} | 114480 |
| Fanconi anemia complementation group R | Alliance | Fanconi anemia, complementation group R | 617244 |
| mirror movements 2 | Alliance | Mirror movements 2 | 614508 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Fanconi anemia | rad51sa23805/sa23805 | standard conditions | Botthof et al., 2017 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003593 | AAA+ ATPase domain |
| Domain | IPR013632 | DNA recombination and repair protein Rad51-like, C-terminal |
| Domain | IPR020587 | DNA recombination and repair protein RecA, monomer-monomer interface |
| Domain | IPR020588 | DNA recombination and repair protein RecA-like, ATP-binding domain |
| Family | IPR011941 | DNA recombination/repair protein Rad51 |
| Family | IPR016467 | DNA recombination and repair protein, RecA-like |
| Homologous_superfamily | IPR010995 | DNA repair Rad51/transcription factor NusA, alpha-helical |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Additional Resources | Length | AAA+ ATPase domain | DNA recombination and repair protein Rad51-like, C-terminal | DNA recombination and repair protein, RecA-like | DNA recombination and repair protein RecA-like, ATP-binding domain | DNA recombination and repair protein RecA, monomer-monomer interface | DNA recombination/repair protein Rad51 | DNA repair Rad51/transcription factor NusA, alpha-helical | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q5TYR1 | InterPro | 340 |
Interactions and Pathways
No data available
Plasmids
No data available