Gene
wls
- ID
- ZDB-GENE-040426-2161
- Name
- Wnt ligand secretion mediator
- Symbol
- wls Nomenclature History
- Previous Names
-
- gpr177
- id:ibd2010
- sb:cb610
- wu:fb36d04
- wu:fb44d10
- wu:fb50c06
- zgc:64091
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable Wnt-protein binding activity. Acts upstream of or within several processes, including brain development; chondrocyte activation; and skeletal system development. Predicted to be located in Golgi membrane and cytoplasmic vesicle membrane. Predicted to be active in endomembrane system and organelle membrane. Is expressed in several structures, including central nervous system; head; inner ear; midbrain neural keel; and neural tube. Human ortholog(s) of this gene implicated in Zaki syndrome. Orthologous to human WLS (Wnt ligand secretion mediator).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 24 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb610 (29 images)
Wild Type Expression Summary
- All Phenotype Data
- 25 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Zaki syndrome | Alliance | Zaki syndrome | 619648 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Protein wntless | Wntless, GOLD domain | Wntless-like, transmembrane domain |
|---|---|---|---|---|---|
| UniProtKB:Q7T357 | InterPro | 542 | |||
| UniProtKB:F2Z4U3 | InterPro | 542 |
Interactions and Pathways
No data available
Plasmids
No data available