ZFIN is now using GRCz12tu for Genomic Data
Gene
ndufs8a
- ID
- ZDB-GENE-040426-2153
- Name
- NADH:ubiquinone oxidoreductase core subunit S8a
- Symbol
- ndufs8a Nomenclature History
- Previous Names
-
- ndufs8
- wu:fb30b07
- zgc:65835
- zgc:77840 (1)
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable 4 iron, 4 sulfur cluster binding activity and NADH dehydrogenase (ubiquinone) activity. Predicted to contribute to NADH dehydrogenase activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone and mitochondrial respiratory chain complex I assembly. Predicted to be located in membrane and mitochondrion. Predicted to be part of respiratory chain complex I. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 2. Orthologous to human NDUFS8 (NADH:ubiquinone oxidoreductase core subunit S8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:65835 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| nuclear type mitochondrial complex I deficiency 2 | Alliance | Mitochondrial complex I deficiency, nuclear type 2 | 618222 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | 4Fe-4S ferredoxin, iron-sulphur binding, conserved site | 4Fe-4S ferredoxin-type, iron-sulphur binding domain | NADH-quinone oxidoreductase, chain I |
|---|---|---|---|---|---|
| UniProtKB:Q6P0T0 | InterPro | 210 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ndufs8a-201
(1)
|
Ensembl | 1,575 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers