Gene
fbxo32
- ID
- ZDB-GENE-040426-1040
- Name
- F-box protein 32
- Symbol
- fbxo32 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Acts upstream of or within several processes, including cardiac muscle tissue morphogenesis; larval locomotory behavior; and muscle cell cellular homeostasis. Located in cytoplasm. Is expressed in cardiac muscle cell; muscle; skeletal muscle; skeletal muscle cell; and yolk syncytial layer. Orthologous to human FBXO32 (F-box protein 32).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56479 (3 images)
Wild Type Expression Summary
- All Phenotype Data
- 6 figures from Bühler et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la027713Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| pc57 | Allele with one insertion | Unknown | Unknown | CRISPR | |
| pc58 | unknown | Unknown | Unknown | zinc finger nuclease | |
| sa6431 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa8703 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa9611 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-fbxo32 | Ruparelia et al., 2024 | |
| MO1-fbxo32 | N/A | Hanai et al., 2007 |
| MO2-fbxo32 | N/A | Hanai et al., 2007 |
| MO3-fbxo32 | N/A | Bühler et al., 2016 |
| MO4-fbxo32 | N/A | Bühler et al., 2016 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | F-box domain | F-box-like domain superfamily | F-box only protein 25/32 |
|---|---|---|---|---|---|
| UniProtKB:Q7ZTY2 | InterPro | 356 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
fbxo32-201
(1)
|
Ensembl | 1,752 nt | ||
| ncRNA |
fbxo32-002
(1)
|
Ensembl | 607 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-fbxo32 | polyclonal | Rabbit |
|
ECM Biosciences LLC
|
3 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-29H14 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:56479 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200917 (1) | 1804 nt | ||
| Genomic | GenBank:BX571853 (2) | 191052 nt | ||
| Polypeptide | UniProtKB:Q7ZTY2 (1) | 356 aa |
- Hsu, T.C., Chiang, C.H., Liu, I.H., Wang, C.Y., Chen, C.Y. (2024) Long-Term Yo-Yo Dieting Exaggerates Liver Steatosis and Lesions but Preserves Muscle Performance in Male Zebrafish. International Journal of Molecular Sciences. 25(23):
- Ranasinghe, T., Seo, Y., Park, H.C., Choe, S.K., Cha, S.H. (2024) Rotenone exposure causes features of Parkinson`s disease pathology linked with muscle atrophy in developing zebrafish embryo. Journal of hazardous materials. 480:136215136215
- Ruparelia, A.A., Montandon, M., Merriner, J., Huang, C., Wong, S.F.L., Sonntag, C., Hardee, J.P., Lynch, G.S., Miles, L.B., Siegel, A., Hall, T.E., Schittenhelm, R.B., Currie, P.D. (2024) Atrogin-1 promotes muscle homeostasis by regulating levels of endoplasmic reticulum chaperone BiP. JCI insight. 9(8):
- Chen, Z.L., Guo, C., Zou, Y.Y., Feng, C., Yang, D.X., Sun, C.C., Wen, W., Jian, Z.J., Zhao, Z., Xiao, Q., Lan-Zheng, ., Peng, X.Y., Zhou, Z.Q., Tang, C.F. (2023) Aerobic exercise enhances mitochondrial homeostasis to counteract D-galactose-induced sarcopenia in zebrafish. Experimental gerontology. 180:112265
- Ikeda, D., Fujita, S., Toda, K., Yaginuma, Y., Kan-No, N., Watabe, S. (2023) Cold-induced muscle atrophy in zebrafish: Insights from swimming activity and gene expression analysis. Biochemistry and biophysics reports. 36:101570101570
- Wen, W., Guo, C., Chen, Z., Yang, D., Zhu, D., Jing, Q., Zheng, L., Sun, C., Tang, C. (2023) Regular exercise attenuates alcoholic myopathy in zebrafish by modulating mitochondrial homeostasis. PLoS One. 18:e0294700e0294700
- Liu, R., Long, Y., Liu, R., Song, G., Li, Q., Yan, H., Cui, Z. (2022) Understanding the Function and Mechanism of Zebrafish Tmem39b in Regulating Cold Resistance. International Journal of Molecular Sciences. 23(19):
- Niedbalska-Tarnowska, J., Ochenkowska, K., Migocka-Patrzałek, M., Dubińska-Magiera, M. (2022) Assessment of the Preventive Effect of L-carnitine on Post-statin Muscle Damage in a Zebrafish Model. Cells. 11(8):
- Sugasawa, T., Komine, R., Manevich, L., Tamai, S., Takekoshi, K., Kanki, Y. (2022) Gene Expression Profile Provides Novel Insights of Fasting-Refeeding Response in Zebrafish Skeletal Muscle. Nutrients. 14(11)
- Sun, C.C., Yang, D., Chen, Z.L., Xiao, J.L., Xiao, Q., Li, C.L., Zhou, Z.Q., Peng, X.Y., Tang, C.F. (2022) Exercise intervention mitigates zebrafish age-related sarcopenia via alleviating mitochondrial dysfunction. The FEBS journal. 290(6):1519-1530
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