ZFIN is now using GRCz12tu for Genomic Data
Gene
tktb
- ID
- ZDB-GENE-030909-13
- Name
- transketolase b
- Symbol
- tktb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable thiamine pyrophosphate binding activity and transketolase activity. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alar plate midbrain region; digestive system; eye; midbrain; and yolk. Orthologous to several human genes including TKTL2 (transketolase like 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb860 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Short stature, developmental delay, and congenital heart defects | 617044 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR020826 | Transketolase binding site |
| Domain | IPR005474 | Transketolase, N-terminal |
| Domain | IPR005475 | Transketolase-like, pyrimidine-binding domain |
| Domain | IPR033248 | Transketolase, C-terminal domain |
| Family | IPR051424 | Transketolase-like |
| Homologous_superfamily | IPR009014 | Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II |
| Homologous_superfamily | IPR029061 | Thiamin diphosphate-binding fold |
Domain Details Per Protein
| Protein | Additional Resources | Length | Thiamin diphosphate-binding fold | Transketolase binding site | Transketolase, C-terminal domain | Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II | Transketolase-like | Transketolase-like, pyrimidine-binding domain | Transketolase, N-terminal |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6PHI8 | InterPro | 625 | |||||||
| UniProtKB:A0A8M9PWD4 | InterPro | 579 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers