Gene
anxa6
- ID
- ZDB-GENE-030707-3
- Name
- annexin A6
- Symbol
- anxa6 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable calcium-dependent phospholipid binding activity and phosphatidylserine binding activity. Acts upstream of or within plasma membrane repair. Predicted to be located in melanosome. Predicted to be active in cytoplasm; sarcolemma; and vesicle membrane. Is expressed in several structures, including cardiovascular system; dermis; musculature system; otic vesicle; and yolk syncytial layer. Orthologous to human ANXA6 (annexin A6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6894167 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Roostalu et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Annexin | Annexin A6 | Annexin repeat | Annexin repeat, conserved site | Annexin superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:A8KBY8 | InterPro | 667 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-131O13 | ZFIN Curated Data | |
| Contained in | BAC | CH73-288L11 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6894167 | Thisse et al., 2004 | |
| Encodes | EST | fc20a07 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:91943 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174386 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193045 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002038 (1) | 2418 nt | ||
| Genomic | GenBank:CU694384 (2) | 111576 nt | ||
| Polypeptide | UniProtKB:A8KBY8 (1) | 667 aa |
- Buglo, E., Sarmiento, E., Martuscelli, N.B., Sant, D.W., Danzi, M.C., Abrams, A.J., Dallman, J.E., Züchner, S. (2020) Genetic compensation in a stable slc25a46 mutant zebrafish: A case for using F0 CRISPR mutagenesis to study phenotypes caused by inherited disease. PLoS One. 15:e0230566
- Lin, J., Liang, J., Wen, J., Luo, M., Li, J., Sun, X., Xu, X., Li, J., Wang, D., Wang, J., Chen, H., Lai, R., Liang, F., Li, C., Ye, F., Zhang, J., Zeng, J., Yang, S., Sheng, W. (2020) Mutations of RNF213 are responsible for sporadic cerebral cavernous malformation and lead to a mulberry-like cluster in zebrafish. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 41(6):1251-1263
- Qiu, W., Fang, M., Magnuson, J.T., Greer, J.B., Chen, Q., Zheng, Y., Xiong, Y., Luo, S., Zheng, C., Schlenk, D. (2020) Maternal exposure to environmental antibiotic mixture during gravid period predicts gastrointestinal effects in zebrafish offspring. Journal of hazardous materials. 399:123009
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Shen, H., Shin, E.M., Lee, S., Mathavan, S., Koh, H., Osato, M., Choi, H., Tergaonkar, V., Korzh, V. (2017) Ikk2 regulates cytokinesis during vertebrate development. Scientific Reports. 7:8094
- Middel, V., Zhou, L., Takamiya, M., Beil, T., Shahid, M., Roostalu, U., Grabher, C., Rastegar, S., Reischl, M., Nienhaus, G.U., Strähle, U. (2016) Dysferlin-mediated phosphatidylserine sorting engages macrophages in sarcolemma repair. Nature communications. 7:12875
- Saxena, S., Purushothaman, S., Meghah, V., Bhatti, B., Poruri, A., Meena Lakshmi, M.G., Sarath Babu, N., Murthy, C.L., Mandal, K.K., Kumar, A., Idris, M.M. (2016) Role of Annexin gene and its regulation during zebrafish caudal fin regeneration. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. 24(3):551-9
- Zhou, X., Yue, G.G., Liu, M., Zuo, Z., Lee, J.K., Li, M., Tsui, S.K., Fung, K.P., Sun, H., Pu, J., Lau, C.B. (2016) Eriocalyxin B, a natural diterpenoid, inhibited VEGF-induced angiogenesis and diminished angiogenesis-dependent breast tumor growth by suppressing VEGFR-2 signaling. Oncotarget. 7(50):82820-82835
- Roostalu, U., and Strähle, U. (2012) In Vivo imaging of molecular interactions at damaged sarcolemma. Developmental Cell. 22(3):515-529
- Gallagher, T.L., Arribere, J.A., Geurts, P.A., Exner, C.R., McDonald, K.L., Dill, K.K., Marr, H.L., Adkar, S.S., Garnett, A.T., Amacher, S.L., and Conboy, J.G. (2011) Rbfox-regulated alternative splicing is critical for zebrafish cardiac and skeletal muscle functions. Developmental Biology. 359(2):251-61
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