ZFIN is now using GRCz12tu for Genomic Data

Gene

si:ch211-204c21.1

ID

ZDB-GENE-030429-35

Name

si:ch211-204c21.1

Symbol

si:ch211-204c21.1 Nomenclature History

Previous Names

sb:cb458

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable cargo receptor activity and clathrin adaptor activity. Predicted to be involved in several processes, including negative regulation of canonical Wnt signaling pathway; positive regulation of endocytosis; and positive regulation of epithelial to mesenchymal transition. Predicted to act upstream of or within cell differentiation. Predicted to be active in clathrin-coated pit and cytoplasm. Is expressed in several structures, including alar plate midbrain region; brain; hypochord; mesoderm; and pectoral fin. Orthologous to human DAB2 (DAB adaptor protein 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from Thisse et al., 2001

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb458 (31 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With si:ch211-204c21.1 Human Ortholog

No data available

Associated With si:ch211-204c21.1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR048559	Disabled homolog 1/2, sulfatide-binding motif
Domain	IPR006020	PTB/PI domain
Domain	IPR048561	Disabled, phosphotyrosine-binding domain
Homologous_superfamily	IPR011993	PH-like domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M9P909	InterPro	668
UniProtKB:A0A8M9QEV1	InterPro	229
UniProtKB:A0A8M9Q4D7	InterPro	419
UniProtKB:A0A8M9PZ11	InterPro	454

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	si:ch211-204c21.1-201 (1) Ensembl	Ensembl	1,885 nt	Select Tool ZFIN BLAST
mRNA	si:ch211-204c21.1-202 (1) Ensembl	Ensembl	1,230 nt	Select Tool ZFIN BLAST
mRNA	si:ch211-204c21.1-203 (1) Ensembl	Ensembl	6,805 nt	Select Tool ZFIN BLAST
mRNA	si:ch211-204c21.1-204 (1) Ensembl	Ensembl	6,317 nt	Select Tool ZFIN BLAST
mRNA	si:ch211-204c21.1-205 (1) Ensembl	Ensembl	6,718 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Genome Browsers

NCBI

ZFIN

Orthology

Comparative Orthology: Alliance

Citations