Gene
sephs3
- ID
- ZDB-GENE-030327-5
- Name
- selenophosphate synthetase 3
- Symbol
- sephs3 Nomenclature History
- Previous Names
-
- sephs2
- sps2
- cb701 (1)
- zgc:92096
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable selenide, water dikinase activity. Predicted to be involved in selenocysteine biosynthetic process. Predicted to act upstream of or within phosphorylation. Predicted to be active in cytoplasm. Is expressed in several structures, including brain; digestive system; immature eye; pronephros; and sensory system. Orthologous to human SEPHS2 (selenophosphate synthetase 2).
- Genome Resources
- Note
-
updated to sephs3 because it has been demonstrated that this gene is not a true ortholog to mammalian (placental) SEPHS2.
- Comparative Information
-
- All Expression Data
- 11 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb701 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR010918 | PurM-like, C-terminal domain |
| Domain | IPR016188 | PurM-like, N-terminal domain |
| Family | IPR004536 | Selenophosphate synthetase |
| Homologous_superfamily | IPR036676 | PurM-like, C-terminal domain superfamily |
| Homologous_superfamily | IPR036921 | PurM-like, N-terminal domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | PurM-like, C-terminal domain | PurM-like, C-terminal domain superfamily | PurM-like, N-terminal domain | PurM-like, N-terminal domain superfamily | Selenophosphate synthetase |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q66I14 | InterPro | 447 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
sephs2-201
(1)
|
Ensembl | 3,429 nt | ||
| mRNA |
sephs2-202
(1)
|
Ensembl | 5,707 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-272P8 | ZFIN Curated Data | |
| Encodes | EST | cb701 | Thisse et al., 2001 | |
| Encodes | cDNA | MGC:92096 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001004295 (1) | 3455 nt | ||
| Genomic | GenBank:CR354375 (1) | 133570 nt | ||
| Polypeptide | UniProtKB:Q66I14 (1) | 447 aa |
No data available
- Schoenmakers, E., Marelli, F., Jørgensen, H.F., Visser, W.E., Moran, C., Groeneweg, S., Avalos, C., Jurgens, S.J., Figg, N., Finigan, A., Wali, N., Agostini, M., Wardle-Jones, H., Lyons, G., Rusk, R., Gopalan, D., Twiss, P., Visser, J.J., Goddard, M., Nashef, S.A.M., Heijmen, R., Clift, P., Sinha, S., Pirruccello, J.P., Ellinor, P.T., Busch-Nentwich, E.M., Ramirez-Solis, R., Murphy, M.P., Persani, L., Bennett, M., Chatterjee, K. (2023) Selenoprotein deficiency disorder predisposes to aortic aneurysm formation. Nature communications. 14:79947994
- Li, X., Liu, H., Li, D., Lei, H., Wei, X., Schlenk, D., Mu, J., Chen, H., Yan, B., Xie, L. (2021) Dietary Seleno-l-Methionine Causes Alterations in Neurotransmitters, Ultrastructure of the Brain, and Behaviors in Zebrafish (Danio rerio). Environmental science & technology. 55:11894-11905
- Betancor, M.B., Almaida-Pagán, P.F., Sprague, M., Hernández, A., Tocher, D.R. (2015) Roles of selenoprotein antioxidant protection in zebrafish, Danio rerio, subjected to dietary oxidative stress. Fish physiology and biochemistry. 41(3):705-20
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Penglase, S., Hamre, K., Ellingsen, S. (2014) Selenium prevents downregulation of antioxidant selenoprotein genes by methylmercury. Free radical biology & medicine. 75:95-104
- Chitramuthu, B.P., Baranowski, D.C., Cadieux, B., Rousselet, E., Seidah, N.G., and Bennett, H.P. (2010) Molecular cloning and embryonic expression of zebrafish PCSK5 co-orthologues: Functional assessment during lateral line development. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(11):2933-2946
- Thisse, C., Degrave, A., Kryukov, G.V., Gladyshev, V.N., Obrecht-Pflumio, S., Krol, A., Thisse, B., and Lescure, A. (2003) Spatial and temporal expression patterns of selenoprotein genes during embryogenesis in zebrafish. Gene expression patterns : GEP. 3(4):525-532
- Sapède, D., Gompel, N., Dambly-Chaudière, C., and Ghysen, A. (2002) Cell migration in the postembryonic development of the fish lateral line. Development (Cambridge, England). 129:605-615
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
- Gompel, N., Cubedo, N., Thisse, C., Thisse, B., Dambly-Chaudiere, C., and Ghysen, A. (2001) Pattern formation in the lateral line of zebrafish. Mechanisms of Development. 105(1-2):69-77
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