Gene

loxl3b

ID

ZDB-GENE-030131-8210

Name

lysyl oxidase-like 3b

Symbol

loxl3b Nomenclature History

Previous Names

fj60c12
im:7157119
wu:fj60c12
zgc:162959

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to enable fibronectin binding activity and protein-lysine 6-oxidase activity. Acts upstream of or within embryonic viscerocranium morphogenesis. Predicted to be located in cytoplasm and nucleus. Predicted to be active in extracellular space. Is expressed in several structures, including axis; head; mesoderm; pectoral fin cartilage; and yolk syncytial layer. Human ortholog(s) of this gene implicated in myopia. Orthologous to human LOXL3 (lysyl oxidase like 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

23 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7149527 (3 images)
IMAGE:7140246 (12 images)
IMAGE:7157119 (28 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With loxl3b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Myopia 28, autosomal recessive	619781

Associated With loxl3b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019828	Lysyl oxidase, conserved site
Domain	IPR001190	SRCR domain
Family	IPR001695	Lysyl oxidase
Family	IPR050912	Lysyl oxidase-like protein
Homologous_superfamily	IPR036772	SRCR-like domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:B8A5R6	InterPro
UniProtKB:B8A5R8	InterPro
UniProtKB:B8A4W9	InterPro	807
UniProtKB:A0A8M3B7U8	InterPro	797
UniProtKB:A0A8M9Q9L1	InterPro	832
UniProtKB:A0A8M6Z3R1	InterPro	849
UniProtKB:A0A8M3AYX6	InterPro	755
UniProtKB:A0A8M3B524	InterPro	792
UniProtKB:A0AB32U161	InterPro	740
UniProtKB:A0AB32U3F9	InterPro	781

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	loxl3b-201 (1) Ensembl	Ensembl	1,489 nt	Select Tool ZFIN BLAST
mRNA	loxl3b-202 (1) Ensembl	Ensembl	1,274 nt	Select Tool ZFIN BLAST
mRNA	loxl3b-203 (1) Ensembl	Ensembl	2,607 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations