Gene

clca1

ID

ZDB-GENE-030131-6221

Name

chloride channel accessory 1

Symbol

clca1 Nomenclature History

Previous Names

fi39d11
wu:fi39d11

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in asthma and chronic obstructive pulmonary disease. Orthologous to several human genes including CLCA1 (chloride channel accessory 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa1839	Allele with one point mutation	Unknown	Splice Site	ENU	Zebrafish International Resource Center (ZIRC) (order this)
sa9888	Allele with one point mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa24978	Allele with one point mutation	Unknown	Splice Site	ENU

1 - 3 of 3

Show

Sequence Targeting Reagents

No data available

Human Disease

Associated With clca1 Human Ortholog

No data available

Associated With clca1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR002035	von Willebrand factor, type A
Domain	IPR013642	Calcium-activated chloride channel, N-terminal
Family	IPR051266	Calcium-activated chloride channel regulator
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036465	von Willebrand factor A-like domain superfamily

1 - 5 of 5

Domain Details Per Protein

Protein	Additional Resources	Length	Calcium-activated chloride channel, N-terminal	Calcium-activated chloride channel regulator	Immunoglobulin-like fold	von Willebrand factor A-like domain superfamily	von Willebrand factor, type A
UniProtKB:X1WHI8	InterPro	903
UniProtKB:A0AB32T152	InterPro	945

1 - 2 of 2

Transcripts

Genome Browsers

Genome Build: GRCz11Chromosome: 15

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	clca1-201 (1) Ensembl	Ensembl		3,412 nt	Select Tool ZFIN BLAST

1 - 1 of 1

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	CH211-116O3	BX927244
Encodes	EST	fi39d11	AW171343 AW174117

1 - 2 of 2

Show

Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001305589 (1)	3055 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CR848009 (1)	157273 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A0AB32T152 (1)	945 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance

Species	Symbol	Chromosome	Accession #	Evidence
Human	CLCA1	1	Ensembl:ENSG00000016490 Gene:1179 HGNC:2015 OMIM:603906	Amino acid sequence comparison (1)

Citations

Include unpublished citations

Sato, Y., Hashiguchi, Y., and Nishida, M. (2009) Temporal pattern of loss/persistence of duplicate genes involved in signal transduction and metabolic pathways after teleost-specific genome duplication. BMC Evolutionary Biology. 9:127

1 - 1 of 1

Show