Gene
sppl2
- ID
- ZDB-GENE-030131-4265
- Name
- signal peptide peptidase-like 2
- Symbol
- sppl2 Nomenclature History
- Previous Names
-
- wu:fc16e01
- wu:fc85d12
- zgc:136525
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable aspartic endopeptidase activity, intramembrane cleaving. Acts upstream of or within negative regulation of coagulation. Predicted to be located in Golgi membrane; endosome membrane; and plasma membrane. Predicted to be active in bounding membrane of organelle and endoplasmic reticulum membrane. Orthologous to human SPPL2B (signal peptide peptidase like 2B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Krawitz et al., 2005
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Pickart et al., 2006
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | PA domain | PA domain superfamily | Peptidase A22B, signal peptide peptidase | Presenilin/signal peptide peptidase |
|---|---|---|---|---|---|---|
| UniProtKB:F1QYI0 | InterPro | 555 | ||||
| UniProtKB:A0A8M9QFY1 | InterPro | 504 | ||||
| UniProtKB:A0A8M9QFX8 | InterPro | 529 |
Interactions and Pathways
No data available
Plasmids
No data available