Gene
daam1b
- ID
- ZDB-GENE-030131-4212
- Name
- dishevelled associated activator of morphogenesis 1b
- Symbol
- daam1b Nomenclature History
- Previous Names
-
- daam1l
- fc83b10
- si:ch211-87i20.1 (1)
- wu:fc83b10
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable actin binding activity and small GTPase binding activity. Acts upstream of or within convergent extension. Predicted to be active in stress fiber. Is expressed in axis; notochord; and polster. Orthologous to human DAAM1 (dishevelled associated activator of morphogenesis 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2005
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu475 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Kida et al., 2007
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa300 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa23682 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa32288 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa45695 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Armadillo-like helical | Armadillo-type fold | Formin, FH2 domain | Formin, FH2 domain superfamily | Formin, FH3 domain | Formin, GTPase-binding domain | Formin Homology | Rho GTPase-binding/formin homology 3 (GBD/FH3) domain |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:B3DJI0 | InterPro | 1069 | ||||||||
| UniProtKB:Q5RHJ3 | InterPro | 1079 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
daam1b-201
(1)
|
Ensembl | 3,948 nt | ||
| mRNA |
daam1b-202
(1)
|
Ensembl | 3,359 nt | ||
| mRNA |
daam1b-205
(1)
|
Ensembl | 3,240 nt | ||
| ncRNA |
daam1b-002
(1)
|
Ensembl | 515 nt | ||
| ncRNA |
daam1b-003
(1)
|
Ensembl | 459 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-87I20 | ZFIN Curated Data | |
| Contained in | BAC | CH211-207I1 | ZFIN Curated Data | |
| Contained in | BAC | RP71-4M17 | ZFIN Curated Data | |
| Encodes | EST | 069-d07-2 | ZFIN Curated Data | |
| Encodes | EST | eu475 | Thisse et al., 2005 | |
| Encodes | EST | fc83b10 | ||
| Encodes | cDNA | MGC:195011 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001030136 (1) | 3240 nt | ||
| Genomic | GenBank:BX296520 (1) | 135280 nt | ||
| Polypeptide | UniProtKB:Q5RHJ3 (1) | 1079 aa |
- Baniel, A., Ziv, L., Ben-Moshe, Z., Sarig, O., Mohamad, J., Peled, A., Rechavi, G., Gothilf, Y., Sprecher, E. (2022) Cutaneous and Developmental Effects of CARD14 Overexpression in Zebrafish. Biomedicines. 10(12):
- Banu, S., Gaur, N., Nair, S., Ravikrishnan, T., Khan, S., Mani, S., Bharathi, S., Mandal, K., Kuram, N.A., Vuppaladadium, S., Ravi, R., Murthy, C.L.N., Quoseena, M., Babu, N.S., Idris, M.M. (2022) Transcriptomic and proteomic analysis of epimorphic regeneration in zebrafish caudal fin tissue. Genomics. 114(2):110300
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Reeves, W.M., Wu, Y., Harder, M.J., Veeman, M.T. (2017) Functional and evolutionary insights from the Ciona notochord transcriptome.. Development (Cambridge, England). 144:3375-3387
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Colombo, A., Palma, K., Armijo, L., Mione, M., Signore, I.A., Morales, C., Guerrero, N., Meynard, M.M., Pérez, R., Suazo, J., Marcelain, K., Briones, L., Härtel, S., Wilson, S.W., and Concha, M.L. (2013) Daam1a mediates asymmetric habenular morphogenesis by regulating dendritic and axonal outgrowth. Development (Cambridge, England). 140(19):3997-4007
- Gordon, L.R., Gribble, K.D., Syrett, C.M., and Granato, M. (2012) Initiation of synapse formation by Wnt-induced MuSK endocytosis. Development (Cambridge, England). 139(5):1023-1033
- Hirayama, J., Miyamura, N., Uchida, Y., Asaoka, Y., Honda, R., Sawanobori, K., Todo, T., Yamamoto, T., Sassone-Corsi, P., and Nishina, H. (2009) Common light signaling pathways controlling DNA repair and circadian clock entrainment in zebrafish. Cell cycle (Georgetown, Tex.). 8(17):2794-2801
- Kassahn, K.S., Dang, V.T., Wilkins, S.J., Perkins, A.C., and Ragan, M.A. (2009) Evolution of gene function and regulatory control after whole-genome duplication: Comparative analyses in vertebrates. Genome research. 19(8):1404-1418
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