Gene
col4a5
- ID
- ZDB-GENE-030131-2281
- Name
- collagen, type IV, alpha 5 (Alport syndrome)
- Symbol
- col4a5 Nomenclature History
- Previous Names
-
- dragnet (1)
- drg
- wu:fc02g11
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to be an extracellular matrix structural constituent conferring tensile strength. Acts upstream of or within axonogenesis and basement membrane organization. Predicted to be located in extracellular region and membrane. Predicted to be part of collagen trimer. Predicted to be active in basement membrane and extracellular space. Is expressed in several structures, including digestive system; integument; nervous system; neural tube; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Alport syndrome and X-linked Alport syndrome. Orthologous to human COL4A5 (collagen type IV alpha 5 chain).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu2431 (19 images)
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la029367Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| s510 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| s530 | unknown | Unknown | Unknown | ENU | |
| sa1609 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa16790 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa21069 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa27050 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa34181 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa41016 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa41017 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 10 of 10
Show
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| X-linked Alport syndrome | Alliance | Alport syndrome 1, X-linked | 301050 |
1 - 1 of 1
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001442 | Collagen IV, non-collagenous |
| Family | IPR050149 | Collagen superfamily |
| Family | IPR050938 | Collagen and Collagen-like Structural Proteins |
| Homologous_superfamily | IPR016187 | C-type lectin fold |
| Homologous_superfamily | IPR036954 | Collagen IV, non-collagenous domain superfamily |
1 - 5 of 6 Show all
Domain Details Per Protein
| Protein | Additional Resources | Length | Collagen and Collagen-like Structural Proteins | Collagen IV, non-collagenous | Collagen IV, non-collagenous domain superfamily | Collagen superfamily | Collagen triple helix repeat | C-type lectin fold |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QBN0 | InterPro | 1685 | ||||||
| UniProtKB:A0A8M2BDZ6 | InterPro | 1679 | ||||||
| UniProtKB:A0A8N7UYU7 | InterPro | 1659 | ||||||
| UniProtKB:A0AB32TWC0 | InterPro | 1679 |
1 - 4 of 4
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
col4a5-201
(1)
|
Ensembl | 6,451 nt | ||
| mRNA |
col4a5-202
(1)
|
Ensembl | 4,980 nt |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-34M5 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-249M16 | ZFIN Curated Data | |
| Encodes | EST | eu2431 | Thisse et al., 2005 | |
| Encodes | EST | fc02g11 | ||
| Encodes | EST | IMAGE:6960791 | ||
| Has Artifact | EST | fc12a01 |
1 - 6 of 6
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001123230 (1) | 4980 nt | ||
| Genomic | GenBank:CR318600 (1) | 257374 nt | ||
| Polypeptide | UniProtKB:A0A8M9QBN0 (1) | 1685 aa |
- LeBleu, V.S., Dai, J., Tsutakawa, S., MacDonald, B.A., Alge, J.L., Sund, M., Xie, L., Sugimoto, H., Tainer, J., Zon, L.I., Kalluri, R. (2023) Identification of unique α4 chain structure and conserved anti-angiogenic activity of α3NC1 type IV collagen in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 252(7):1046-1060
- Vöcking, O., Famulski, J.K. (2023) A temporal single cell transcriptome atlas of zebrafish anterior segment development. Scientific Reports. 13:56565656
- Falat, E.J., Voit, G.C., Gutzman, J.H. (2022) Laminin-111 mutant studies reveal a hierarchy within laminin-111 genes in their requirement for basal epithelial tissue folding. Developmental Biology. 492:172-186
- Naylor, R.W., Lemarie, E., Jackson-Crawford, A., Davenport, J.B., Mironov, A., Lowe, M., Lennon, R. (2022) A novel nanoluciferase transgenic reporter measures proteinuria in zebrafish. Kidney International. 102(4):815-827
- Sarohi, V., Srivastava, S., Basak, T. (2022) Comprehensive Mapping and Dynamics of Site-Specific Prolyl-Hydroxylation, Lysyl-Hydroxylation and Lysyl O-Glycosylation of Collagens Deposited in ECM During Zebrafish Heart Regeneration. Frontiers in molecular biosciences. 9:892763
- Murphy, P.L., Isaacman-Beck, J., Granato, M. (2021) Robo2 drives target-selective peripheral nerve regeneration in response to glia-derived signals. The Journal of neuroscience : the official journal of the Society for Neuroscience. 42(5):762-776
- Sun, J., She, P., Liu, X., Gao, B., Jin, D., Zhong, T.P. (2020) Disruption of Abcc6 Transporter in Zebrafish Causes Ocular Calcification and Cardiac Fibrosis. International Journal of Molecular Sciences. 22(1):
- Nicholas, C., Weaver, M., Piedade, W.P., Vocking, O., Famulski, J.K. (2019) Temporal characterization of optic fissure basement membrane composition suggests nidogen may be an initial target of remodeling. Developmental Biology. 452(1):43-54
- Taler, K., Weiss, O., Rotem, S., Rubinstein, A.M., Seritrakul, P., Gross, J.M., Inbal, A. (2019) Lysyl hydroxylase 3 is required for normal lens capsule formation and maintenance of lens epithelium integrity and fate. Developmental Biology. 458(2):177-188
- Xue, Y., Liu, D., Cui, G., Ding, Y., Ai, D., Gao, S., Zhang, Y., Suo, S., Wang, X., Lv, P., Zhou, C., Li, Y., Chen, X., Peng, G., Jing, N., Han, J.J., Liu, F. (2019) A 3D Atlas of Hematopoietic Stem and Progenitor Cell Expansion by Multi-dimensional RNA-Seq Analysis. Cell Reports. 27:1567-1578.e5
1 - 10 of 28
Show