Gene
cs
- ID
- ZDB-GENE-030131-1058
- Name
- citrate synthase
- Symbol
- cs Nomenclature History
- Previous Names
-
- wu:fb58e04
- zgc:55507
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable citrate (Si)-synthase activity and identical protein binding activity. Acts upstream of or within response to activity. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix. Is expressed in brain; gill; heart; and muscle. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and hypertrophic cardiomyopathy. Orthologous to human CS (citrate synthase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55507 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la022682Tg | Transgenic insertion | Unknown | Unknown | DNA |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR019810 | Citrate synthase active site |
| Family | IPR002020 | Citrate synthase |
| Family | IPR010109 | Citrate synthase, eukaryotic-type |
| Homologous_superfamily | IPR016142 | Citrate synthase-like, large alpha subdomain |
| Homologous_superfamily | IPR016143 | Citrate synthase-like, small alpha subdomain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Citrate synthase | Citrate synthase active site | Citrate synthase, eukaryotic-type | Citrate synthase-like, large alpha subdomain | Citrate synthase-like, small alpha subdomain | Citrate synthase superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:B2GT34 | InterPro | 468 | ||||||
| UniProtKB:Q7ZVY5 | InterPro | 468 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-190G6 | ZFIN Curated Data | |
| Contains | SNP | rs3729275 | ZFIN Curated Data | |
| Contains | SNP | rs3729276 | ZFIN Curated Data | |
| Contains | SNP | rs3729277 | ZFIN Curated Data | |
| Contains | SNP | rs3729278 | ZFIN Curated Data | |
| Encodes | EST | fb58e04 | ||
| Encodes | cDNA | MGC:55507 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:175079 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192831 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199598 (1) | 3137 nt | ||
| Genomic | GenBank:CR381531 (1) | 149672 nt | ||
| Polypeptide | UniProtKB:B2GT34 (1) | 468 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | CS | 12 | Amino acid sequence comparison (2) |
- Lavorato, M., Iadarola, D., Remes, C., Kaur, P., Broxton, C., Mathew, N.D., Xiao, R., Seiler, C., Nakamaru-Ogiso, E., Anderson, V.E., Falk, M.J. (2024) dldhcri3 zebrafish exhibited altered mitochondrial ultrastructure, morphology and dysfunction partially rescued by probucol or thiamine. JCI insight. 9(18):
- Wang, J.X., Zhang, Y.Y., Qian, Y.C., Qian, Y.F., Jin, A.H., Wang, M., Luo, Y., Qiao, F., Zhang, M.L., Chen, L.Q., Du, Z.Y. (2024) Inhibition of mitochondrial citrate shuttle alleviates metabolic syndromes induced by high-fat diet. American journal of physiology. Cell physiology. 327(3):C737-C749
- Ivantsova, E., Wengrovitz, A.S., Souders, C.L., Martyniuk, C.J. (2022) Developmental and behavioral toxicity assessment of glyphosate and its main metabolite aminomethylphosphonic acid (AMPA) in zebrafish embryos/larvae. Environmental Toxicology and Pharmacology. 93:103873
- Kurchaba, N., Charette, J.M., LeMoine, C.M.R. (2022) Metabolic consequences of PGC-1α dysregulation in adult zebrafish muscle. American journal of physiology. Regulatory, integrative and comparative physiology. 323(3):R319-R330
- Morgan, R., Andreassen, A.H., Åsheim, E.R., Finnøen, M.H., Dresler, G., Brembu, T., Loh, A., Miest, J.J., Jutfelt, F. (2022) Reduced physiological plasticity in a fish adapted to stable temperatures. Proceedings of the National Academy of Sciences of the United States of America. 119:e2201919119
- van de Pol, I.L.E., Hermaniuk, A., Verberk, W.C.E.P. (2021) Interacting Effects of Cell Size and Temperature on Gene Expression, Growth, Development and Swimming Performance in Larval Zebrafish. Frontiers in Physiology. 12:738804
- Chen, L., Lam, J.C., Tang, L., Hu, C., Liu, M., Lam, P.K.S., Zhou, B. (2020) Probiotic modulation of lipid metabolism disorders caused by perfluorobutanesulfonate pollution in zebrafish. Environmental science & technology. 54(12):7494-7503
- Lee, H., Ko, E., Shin, S., Choi, M., Kim, K.T. (2020) Differential mitochondrial dysregulation by exposure to individual organochlorine pesticides (OCPs) and their mixture in zebrafish embryos. Environmental pollution (Barking, Essex : 1987). 277:115904
- Zhu, Q.S., Wang, J., He, S., Liang, X.F., Xie, S., Xiao, Q.Q. (2020) Early leucine programming on protein utilization and mTOR signaling by DNA methylation in zebrafish (Danio rerio). Nutrition & metabolism. 17:67
- Northam, C., LeMoine, C.M.R. (2019) Metabolic regulation by the PGC-1α and PGC-1β coactivators in larval zebrafish (Danio rerio). Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 234:60-67
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