Gene
gapdh
- ID
- ZDB-GENE-030115-1
- Name
- glyceraldehyde-3-phosphate dehydrogenase
- Symbol
- gapdh Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity; microtubule binding activity; and peptidyl-cysteine S-nitrosylase activity. Predicted to be involved in several processes, including peptidyl-cysteine S-trans-nitrosylation; positive regulation of canonical NF-kappaB signal transduction; and protein stabilization. Predicted to act upstream of or within apoptotic process and glucose metabolic process. Predicted to be located in cytoplasm; microtubule cytoskeleton; and nucleus. Predicted to be active in cytosol. Is expressed in several structures, including cardiovascular system; integument; musculature system; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human GAPDH (glyceraldehyde-3-phosphate dehydrogenase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 43 figures from 31 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb609 (28 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR020830 | Glyceraldehyde 3-phosphate dehydrogenase, active site |
| Domain | IPR020828 | Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain |
| Domain | IPR020829 | Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain |
| Family | IPR006424 | Glyceraldehyde-3-phosphate dehydrogenase, type I |
| Family | IPR020831 | Glyceraldehyde/Erythrose phosphate dehydrogenase family |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Glyceraldehyde 3-phosphate dehydrogenase, active site | Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain | Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain | Glyceraldehyde-3-phosphate dehydrogenase, type I | Glyceraldehyde/Erythrose phosphate dehydrogenase family | NAD(P)-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q5XJ10 | InterPro | 333 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-260G12 | ZFIN Curated Data | |
| Encodes | EST | bb02e05 | ||
| Encodes | EST | cb609 | Thisse et al., 2001 | |
| Encodes | EST | fb33a10 | ZFIN Curated Data | |
| Encodes | EST | ft80f05 | ||
| Encodes | cDNA | MGC:86789 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:110724 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001115114 (1) | 1329 nt | ||
| Genomic | GenBank:CU861451 (2) | 120950 nt | ||
| Polypeptide | UniProtKB:Q5XJ10 (1) | 333 aa |
- Spampinato, M., Giallongo, C., Giallongo, S., Spina, E., Duminuco, A., Longhitano, L., Caltabiano, R., Salvatorelli, L., Broggi, G., Pricoco, E.P., Del Fabro, V., Dulcamare, I., DI Mauro, A.M., Romano, A., Di Raimondo, F., Li Volti, G., Palumbo, G.A., Tibullo, D. (2025) Lactate accumulation promotes immunosuppression and fibrotic transformation of bone marrow microenvironment in myelofibrosis. Journal of translational medicine. 23:6969
- Aranda-Martínez, P., Sayed, R.K.A., Fernández-Martínez, J., Ramírez-Casas, Y., Yang, Y., Escames, G., Acuña-Castroviejo, D. (2024) Zebrafish as a Human Muscle Model for Studying Age-Dependent Sarcopenia and Frailty. International Journal of Molecular Sciences. 25(11):
- Bao, J., Su, B., Chen, Z., Sun, Z., Peng, J., Zhao, S. (2024) A UTP3-dependent nucleolar translocation pathway facilitates pre-rRNA 5'ETS processing. Nucleic acids research. 52(16):9671-9694
- Brañas Casas, R., Zuppardo, A., Risato, G., Dinarello, A., Celeghin, R., Fontana, C., Grelloni, E., Gilea, A.I., Viscomi, C., Rasola, A., Dalla Valle, L., Lodi, T., Baruffini, E., Facchinello, N., Argenton, F., Tiso, N. (2024) Zebrafish polg2 knock-out recapitulates human POLG-disorders; implications for drug treatment. Cell Death & Disease. 15:281281
- Burkhalter, M.D., Stiff, T., Maerz, L.D., Casar Tena, T., Wiese, H., Gerhards, J., Sailer, S.A., Vu, L.A.T., Duong Phu, M., Donow, C., Alupei, M., Iben, S., Groth, M., Wiese, S., Church, J.A., Jeggo, P.A., Philipp, M. (2024) Cilia defects upon loss of WDR4 are linked to proteasomal hyperactivity and ubiquitin shortage. Cell Death & Disease. 15:660660
- Dill, H., Liewald, J.F., Becker, M., Seidenthal, M., Gottschalk, A. (2024) Neuropeptidergic regulation of neuromuscular signaling in larval zebrafish alters swimming behavior and synaptic transmission. iScience. 27:110687110687
- Ding, Y., Tong, J., Luo, G., Sun, R., Bei, C., Feng, Z., Meng, L., Wang, F., Zhou, J., Chen, Z., Li, D., Fan, Y., Song, S., Wang, D., Feng, C.G., Liu, H., Chen, Q., Yan, B., Gao, Q. (2024) Mycobacterial CpsA activates type I IFN signaling in macrophages via cGAS-mediated pathway. iScience. 27:109807109807
- Gaitán-Peñas, H., Pérez-Rius, C., Muhaisen, A., Castellanos, A., Errasti-Murugarren, E., Barrallo-Gimeno, A., Alcaraz-Pérez, F., Estévez, R. (2024) Characterization of ClC-1 chloride channels in zebrafish: a new model to study myotonia. The Journal of physiology. 602(16):3975-3994
- Gao, Y., Wu, Y., Tie, F., Wang, H. (2024) Stilbenoids from fenugreek seeds alleviate insulin resistance by regulating the PI3K/AKT/mTOR signaling pathway in a type 2 diabetes zebrafish model. Heliyon. 10:e32007e32007
- Germeys, C., Vandoorne, T., Davie, K., Poovathingal, S., Heeren, K., Vermeire, W., Nami, F., Moisse, M., Quaegebeur, A., Sierksma, A., Rué, L., Sicart, A., Eykens, C., De Cock, L., De Strooper, B., Carmeliet, P., Van Damme, P., De Bock, K., Van Den Bosch, L. (2024) Targeting EGLN2/PHD1 protects motor neurons and normalizes the astrocytic interferon response. Cell Reports. 43:114719114719
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