Gene
msna
- ID
- ZDB-GENE-021211-2
- Name
- moesin a
- Symbol
- msna Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable actin binding activity and cell adhesion molecule binding activity. Acts upstream of or within blood vessel lumenization and endoderm development. Predicted to be located in anchoring junction; cytoskeleton; and membrane. Predicted to be active in several cellular components, including adherens junction; filopodium; and microvillus. Is expressed in several structures, including cardiovascular system; gut; hypochord; nervous system; and swim bladder bud. Human ortholog(s) of this gene implicated in immunodeficiency 50. Orthologous to human MSN (moesin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu2457 (12 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| is17Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| is20Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| la024860Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa267 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa1265 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa18450 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20388 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa33578 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-msna | Wierson et al., 2020 | |
| CRISPR2-msna | Wierson et al., 2020 | |
| MO1-msna | N/A | Wang et al., 2010 |
| MO2-msna | N/A | Wang et al., 2010 |
| MO3-msna | N/A | Wang et al., 2010 |
| MO4-msna | N/A | Diz-Munoz et al., 2010 |
| TALEN1-msna | Bedell et al., 2012 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency 50 | Alliance | Immunodeficiency 50 | 300988 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Band 4.1 domain | ERM family, FERM domain C-lobe | Ezrin/radixin/moesin | Ezrin/radixin/moesin, alpha-helical domain | Ezrin/radixin/moesin, C-terminal | Ezrin/radixin/moesin-like | FERM/acyl-CoA-binding protein superfamily | FERM central domain | FERM conserved site | FERM, C-terminal PH-like domain | FERM domain | FERM, N-terminal | FERM superfamily, second domain | Moesin tail domain superfamily | PH-like domain superfamily | Ubiquitin-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q66I42 | InterPro | 579 | ||||||||||||||||
| UniProtKB:A0A8M3AZE1 | InterPro | 443 | ||||||||||||||||
| UniProtKB:A0A8M3B2A2 | InterPro | 568 |
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Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(kdrl:msna-EGFP) |
|
| 1 | (9) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-95F18 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-286F3 | ZFIN Curated Data | |
| Encodes | EST | eu2457 | Thisse et al., 2005 | |
| Encodes | EST | fb14b03 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:85640 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001004296 (1) | 3635 nt | ||
| Genomic | GenBank:CR847858 (1) | 255113 nt | ||
| Polypeptide | UniProtKB:Q66I42 (1) | 579 aa |
- Yang, S., Xu, X., Zhang, A., Wang, Y., Ji, G., Sun, C., Li, H. (2023) The evolution and immunomodulatory role of Zc3h12 proteins in zebrafish (Danio rerio). International journal of biological macromolecules. 239:124214
- Takita, S., Seko, Y. (2020) eys+/- ; lrp5+/- Zebrafish Reveals Lrp5 Can Be the Receptor of Retinol in the Visual Cycle. iScience. 23:101762
- Wierson, W.A., Welker, J.M., Almeida, M.P., Mann, C.M., Webster, D.A., Torrie, M.E., Weiss, T.J., Kambakam, S., Vollbrecht, M.K., Lan, M., McKeighan, K.C., Levey, J., Ming, Z., Wehmeier, A., Mikelson, C.S., Haltom, J.A., Kwan, K.M., Chien, C.B., Balciunas, D., Ekker, S.C., Clark, K.J., Webber, B.R., Moriarity, B.S., Solin, S.L., Carlson, D.F., Dobbs, D.L., McGrail, M., Essner, J. (2020) Efficient targeted integration directed by short homology in zebrafish and mammalian cells. eLIFE. 9:
- Cabezas-Sanchez, P., Rainieri, S., Conlledo, N., Barranco, A., Sanz-Landaluze, J., Camara, C., Luque-Garcia, J.L. (2019) Impact of selenium co-administration on methylmercury exposed eleutheroembryos and adult zebrafish (Danio rerio): Changes in bioaccumulation and gene expression. Chemosphere. 236:124295
- Giffen, K.P., Liu, H., Kramer, K.L., He, D.Z. (2019) Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Frontiers in neuroscience. 13:1117
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Reeves, W.M., Wu, Y., Harder, M.J., Veeman, M.T. (2017) Functional and evolutionary insights from the Ciona notochord transcriptome.. Development (Cambridge, England). 144:3375-3387
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- James, A., Lee, C., Williams, A.M., Angileri, K., Lathrop, K.L., Gross, J.M. (2016) The Hyaloid Vasculature Facilitates Basement Membrane Breakdown During Choroid Fissure Closure in the Zebrafish Eye. Developmental Biology. 419(2):262-272
- Xie, H., Ye, D., Sepich, D., Lin, F. (2016) S1pr2/Gα13 signaling regulates the migration of endocardial precursors by controlling endoderm convergence. Developmental Biology. 414:228-43
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