Gene
mst1
- ID
- ZDB-GENE-020806-3
- Name
- macrophage stimulating 1
- Symbol
- mst1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable receptor tyrosine kinase binding activity. Acts upstream of or within bone mineralization and inflammatory response. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in digestive system; margin; and yolk syncytial layer. Used to study inflammatory bowel disease. Orthologous to several human genes including MST1 (macrophage stimulating 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb981 (7 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| inflammatory bowel disease | mst1t34230/t34230 | standard conditions | Witte et al., 2014 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018056 | Kringle, conserved site |
| Domain | IPR000001 | Kringle |
| Domain | IPR001254 | Serine proteases, trypsin domain |
| Domain | IPR003609 | PAN/Apple domain |
| Family | IPR001314 | Peptidase S1A, chymotrypsin family |
| Family | IPR024174 | Hepatocyte growth factor/Macrophage stimulatory protein |
| Family | IPR050759 | Serine proteases and regulators with kringle domains |
| Homologous_superfamily | IPR009003 | Peptidase S1, PA clan |
| Homologous_superfamily | IPR013806 | Kringle-like fold |
| Homologous_superfamily | IPR038178 | Kringle superfamily |
| Homologous_superfamily | IPR043504 | Peptidase S1, PA clan, chymotrypsin-like fold |
Domain Details Per Protein
| Protein | Additional Resources | Length | Hepatocyte growth factor/Macrophage stimulatory protein | Kringle | Kringle, conserved site | Kringle-like fold | Kringle superfamily | PAN/Apple domain | Peptidase S1A, chymotrypsin family | Peptidase S1, PA clan | Peptidase S1, PA clan, chymotrypsin-like fold | Serine proteases and regulators with kringle domains | Serine proteases, trypsin domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q90ZN6 | InterPro | 709 |
Interactions and Pathways
No data available
Plasmids
No data available