Gene
cyp1a
- ID
- ZDB-GENE-011219-1
- Name
- cytochrome P450, family 1, subfamily A
- Symbol
- cyp1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen and steroid hydroxylase activity. Acts upstream of or within cellular response to xenobiotic stimulus. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in mitochondrion. Is expressed in several structures, including digestive system; pectoral fin bud; pericardial region; tail bud; and vasculature. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); diabetes mellitus (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung disease (multiple). Orthologous to several human genes including CYP1A2 (cytochrome P450 family 1 subfamily A member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 124 figures from 62 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7163229 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cytochrome P450 | Cytochrome P450, conserved site | Cytochrome P450, E-class, group I | Cytochrome P450, E-class, group I, CYP1 | Cytochrome P450 superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q8UW07 | InterPro | 519 |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-cyp1a | monoclonal | IgG3 , k | Mouse |
|
Cayman Chemical Company
Biosense Laboratories |
10 | |
| Ab3-cyp1a | monoclonal | IgG | Mouse |
|
Absolute Biotech
|
2 |
Plasmids
No data available