Gene
angpt1
- ID
- ZDB-GENE-010817-1
- Name
- angiopoietin 1
- Symbol
- angpt1 Nomenclature History
- Previous Names
-
- ang1 (1)
- wu:fc76g06
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable receptor tyrosine kinase binding activity. Acts upstream of or within blood vessel development and brain development. Predicted to be located in extracellular region. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including brain; cardiovascular system; hypochord; medial longitudinal fasciculus; and ventral mesenchyme. Human ortholog(s) of this gene implicated in alcohol dependence; brain ischemia; diabetic retinopathy; hereditary angioedema; and hypertension. Orthologous to human ANGPT1 (angiopoietin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ?Angioedema, hereditary, 5 | 619361 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020837 | Fibrinogen, conserved site |
| Domain | IPR002181 | Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain |
| Family | IPR037579 | Fibrinogen/angiopoietin-like |
| Homologous_superfamily | IPR014716 | Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1 |
| Homologous_superfamily | IPR036056 | Fibrinogen-like, C-terminal |
Domain Details Per Protein
| Protein | Additional Resources | Length | Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain | Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1 | Fibrinogen/angiopoietin-like | Fibrinogen, conserved site | Fibrinogen-like, C-terminal |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q90Z19 | InterPro | 513 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
angpt1-201
(1)
|
Ensembl | 2,164 nt |
Interactions and Pathways
No data available
Plasmids
No data available