Gene
zeb1b
- ID
- ZDB-GENE-010621-1
- Name
- zinc finger E-box binding homeobox 1b
- Symbol
- zeb1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including gastrulation; regulation of cell-cell adhesion involved in gastrulation; and regulation of gastrulation. Predicted to be located in nucleus. Is expressed in several structures, including cranial ganglion; hypoblast; intestine; neural plate; and segmental plate. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy and posterior polymorphous corneal dystrophy 3. Orthologous to human ZEB1 (zinc finger E-box binding homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu530 (16 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la018172Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa2635 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-zeb1b | N/A | Goudarzi et al., 2012 |
| MO2-zeb1b | N/A | Vannier et al., 2013 |
| MO3-zeb1b | N/A | Riazuddin et al., 2010 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Fuchs' endothelial dystrophy | Alliance | Corneal dystrophy, Fuchs endothelial, 6 | 613270 |
| posterior polymorphous corneal dystrophy 3 | Alliance | Corneal dystrophy, posterior polymorphous, 3 | 609141 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Drought induced 19 protein type, zinc-binding domain | Homedomain-like superfamily | Homeodomain | Zinc finger C2H2 superfamily | Zinc finger C2H2-type | Zinc finger E-box-binding homeobox |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QE24 | InterPro | 1064 | ||||||
| UniProtKB:Q9DEH7 | InterPro | 1078 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-52L6 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-148D16 | ZFIN Curated Data | |
| Encodes | EST | eu530 | Thisse et al., 2005 | |
| Encodes | EST | fc24f01 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193647 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131709 (1) | 5299 nt | ||
| Genomic | GenBank:BX470098 (1) | 249826 nt | ||
| Polypeptide | UniProtKB:Q9DEH7 (1) | 1078 aa |
- Deebani, A., Mary, J., Dhinoja, S., Al Qaryoute, A., Fallatah, W., Jagadeeswaran, P. (2025) Knockdown of zebrafish tmem242 enhances the production of ROS that signals to increase f9a expression resulting in DIC-like condition. Scientific Reports. 15:30583058
- Kim, D.H., Kim, E.J., Kim, D.H., Park, S.W. (2020) Dact2 is involved in the regulation of epithelial-mesenchymal transition. Biochemical and Biophysical Research Communications. 524(1):190-197
- Sharma, P., Gupta, S., Chaudhary, M., Mitra, S., Chawla, B., Khursheed, M.A., Saran, N.K., Ramachandran, R. (2020) Biphasic Role of Tgf-β Signaling during Müller Glia Reprogramming and Retinal Regeneration in Zebrafish. iScience. 23:100817
- Sharma, P., Gupta, S., Chaudhary, M., Mitra, S., Chawla, B., Khursheed, M.A., Ramachandran, R. (2019) Oct4 mediates Müller glia reprogramming and cell cycle exit during retina regeneration in zebrafish. Life science alliance. 2(5):
- Mayrhofer, M., Gourain, V., Reischl, M., Affaticati, P., Jenett, A., Joly, J.S., Benelli, M., Demichelis, F., Poliani, P.L., Sieger, D., Mione, M. (2017) A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK/PI3K induced malignant growth. Disease models & mechanisms. 10(1):15-28
- Huang, L., Wang, C., Zhang, Y., Wu, M., and Zuo, Z. (2013) Phenanthrene causes ocular developmental toxicity in zebrafish embryos and the possible mechanisms involved. Journal of hazardous materials. 261C:172-180
- Vannier, C., Mock, K., Brabletz, T., and Driever, W. (2013) Zeb1 regulates E-cadherin and Epcam expression to control cell behavior in early zebrafish development. The Journal of biological chemistry. 288(26):18643-59
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Goudarzi, M., Banisch, T.U., Mobin, M.B., Maghelli, N., Tarbashevich, K., Strate, I., van den Berg, J., Blaser, H., Bandemer, S., Paluch, E., Bakkers, J., Toli-Nørrelykke, I.M., and Raz, E. (2012) Identification and Regulation of a Molecular Module for Bleb-Based Cell Motility. Developmental Cell. 23(1):210-218
- Riazuddin, S.A., Zaghloul, N.A., Al-Saif, A., Davey, L., Diplas, B.H., Meadows, D.N., Eghrari, A.O., Minear, M.A., Li, Y.J., Klintworth, G.K., Afshari, N., Gregory, S.G., Gottsch, J.D., and Katsanis, N. (2010) Missense mutations in TCF8 cause late-onset Fuchs corneal dystrophy and interact with FCD4 on chromosome 9p. American journal of human genetics. 86(1):45-53
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