Gene
pycard
- ID
- ZDB-GENE-000511-2
- Name
- PYD and CARD domain containing
- Symbol
- pycard Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Enables Pyrin domain binding activity. Acts upstream of or within defense response to other organism; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; and regulation of inflammatory response. Part of NLRP1 inflammasome complex and NLRP3 inflammasome complex. Is expressed in several structures, including digestive system; integument; periderm; pleuroperitoneal region; and unfertilized egg. Orthologous to human PYCARD (PYD and CARD domain containing).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 21 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:109874 (8 images)
- eu1007 (8 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hdb10Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| hkz14 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| imb9 | Allele with one deletion | Exon 1 | Unknown | CRISPR | |
| sa42794 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| zf2174 | Allele with one deletion | Exon 1 | Premature Stop | TALEN | |
| zju301 | Allele with one deletion | Exon 1 | Unknown | CRISPR |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | CARD8/ASC/NALP1, CARD domain | CARD domain | DAPIN domain | Death-like domain superfamily | NLRP Inflammasome |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q9I9N6 | InterPro PDB | 203 | |||||
| UniProtKB:Q4VBV3 | InterPro | 203 | |||||
| UniProtKB:A0A8M1PC53 | InterPro | 203 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pycard-201
(1)
|
Ensembl | 916 nt |
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Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(HSE:pycard-mKate2,myl7:TagRFP) |
| 1 | Kuri et al., 2017 | ||
| Tg(UAS:dnpycard-EGFP,myl7:EGFP) |
|
| 1 | (4) | |
| Tg(UAS:pycard-EGFP,myl7:EGFP) |
|
| (3) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-225P5 | ZFIN Curated Data | |
| Encodes | EST | eu1007 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:109874 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191220 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131495 (1) | 916 nt | ||
| Genomic | GenBank:BX649388 (1) | 177865 nt | ||
| Polypeptide | UniProtKB:A0A8M1PC53 (1) | 203 aa |
- Cao, Y., Xu, F., Xia, Q., Liu, K., Lin, H., Zhang, S., Zhang, Y. (2024) The Peptide LLTRAGL Derived from Rapana venosa Exerts Protective Effect against Inflammatory Bowel Disease in Zebrafish Model by Regulating Multi-Pathways. Marine drugs. 22(3):
- Ernst, A., Piragyte, I., Mp, A.M., Le, N.D., Grandgirard, D., Leib, S.L., Oates, A., Mercader, N. (2023) Identification of side effects of COVID-19 drug candidates on embryogenesis using an integrated zebrafish screening platform. Scientific Reports. 13:1703717037
- Ma, Y., Hui, K.L., Gelashvili, Z., Niethammer, P. (2023) Oxoeicosanoid signaling mediates early antimicrobial defense in zebrafish. Cell Reports. 42:111974111974
- Harapas, C.R., Robinson, K.S., Lay, K., Wong, J., Moreno Traspas, R., Nabavizadeh, N., Rass-Rothschild, A., Boisson, B., Drutman, S.B., Laohamonthonkul, P., Bonner, D., Xiong, J.R., Gorrell, M.D., Davidson, S., Yu, C.H., Fleming, M.D., Gudera, J., Stein, J., Ben-Harosh, M., Groopman, E., Shimamura, A., Tamary, H., Kayserili, H., Hatipoğlu, N., Casanova, J.L., Bernstein, J.A., Zhong, F.L., Masters, S.L., Reversade, B. (2022) DPP9 deficiency: An inflammasomopathy that can be rescued by lowering NLRP1/IL-1 signaling. Science immunology. 7:eabi4611
- Lozano-Gil, J.M., Rodríguez-Ruiz, L., Tyrkalska, S.D., García-Moreno, D., Pérez-Oliva, A.B., Mulero, V. (2022) Gasdermin E mediates pyroptotic cell death of neutrophils and macrophages in a zebrafish model of chronic skin inflammation. Developmental and comparative immunology. 132:104404
- Niu, L., Luo, G., Liang, R., Qiu, C., Yang, J., Xie, L., Zhang, K., Tian, Y., Wang, D., Song, S., Takiff, H.E., Wong, K.W., Fan, X., Gao, Q., Yan, B. (2022) Negative Regulator Nlrc3-like Maintain the Balanced Innate Immune Response During Mycobacterial Infection in Zebrafish. Frontiers in immunology. 13:893611
- Shkarina, K., Hasel de Carvalho, E., Santos, J.C., Ramos, S., Leptin, M., Broz, P. (2022) Optogenetic activators of apoptosis, necroptosis, and pyroptosis. The Journal of cell biology. 221(6):
- Tyrkalska, S.D., Martínez-López, A., Arroyo, A.B., Martínez-Morcillo, F.J., Candel, S., García-Moreno, D., Mesa-Del-Castillo, P., Cayuela, M.L., Mulero, V. (2022) Differential proinflammatory activities of Spike proteins of SARS-CoV-2 variants of concern. Science advances. 8:eabo0732
- Tyrkalska, S.D., Martínez-López, A., Pedoto, A., Candel, S., Cayuela, M.L., Mulero, V. (2022) The Spike protein of SARS-CoV-2 signals via Tlr2 in zebrafish. Developmental and comparative immunology. 140:104626
- Tyrkalska, S.D., Pedoto, A., Martínez-López, A., Ros-Lucas, J.A., Mesa-Del-Castillo, P., Candel, S., Mulero, V. (2022) Silica crystals activate toll-like receptors and inflammasomes to promote local and systemic immune responses in zebrafish. Developmental and comparative immunology. 138:104523
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