Gene

melk

ID
ZDB-GENE-990603-5
Name
maternal embryonic leucine zipper kinase
Symbol
melk Nomenclature History
Previous Names
  • fb71b01
  • fe01f04
  • wu:fb71b01 (1)
  • wu:fe01f04 (1)
  • zMelk-like (1)
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to have calcium ion binding activity; non-membrane spanning protein tyrosine kinase activity; and protein serine/threonine kinase activity. Involved in erythrocyte development and regulation of heart contraction. Predicted to localize to cell cortex and nucleus. Is expressed in several structures, including digestive system; immature eye; nervous system; pleuroperitoneal region; and proliferative region. Orthologous to human MELK (maternal embryonic leucine zipper kinase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
7 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from Saito et al., 2005
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With melk Human Ortholog
No data available
Associated With melk Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR001772 Kinase associated domain 1 (KA1)
Domain IPR034673 Maternal embryonic leucine zipper kinase, catalytic domain
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR028375 KA1 domain/Ssp2, C-terminal
Domain Details Per Protein
Protein Length KA1 domain/Ssp2, C-terminal Kinase associated domain 1 (KA1) Maternal embryonic leucine zipper kinase, catalytic domain Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site
UniProtKB:F1QGZ6 676
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations