Gene
fes
- ID
- ZDB-GENE-100812-10
- Name
- FES proto-oncogene, tyrosine kinase
- Symbol
- fes Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to have non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Predicted to be involved in several processes, including peptidyl-tyrosine autophosphorylation; regulation of mast cell degranulation; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to localize to extrinsic component of cytoplasmic side of plasma membrane. Orthologous to human FES (FES proto-oncogene, tyrosine kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Challa et al., 2013
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Thyme et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000980 | SH2 domain |
| Domain | IPR001060 | FCH domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
| Domain | IPR031160 | F-BAR domain |
| Domain | IPR035849 | Fes/Fps/Fer, SH2 domain |
| Family | IPR016250 | Tyrosine-protein kinase, Fes/Fps type |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR027267 | AH/BAR domain superfamily |
| Homologous_superfamily | IPR036860 | SH2 domain superfamily |
Domain Details Per Protein
| Protein | Length | AH/BAR domain superfamily | F-BAR domain | FCH domain | Fes/Fps/Fer, SH2 domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine-threonine/tyrosine-protein kinase, catalytic domain | SH2 domain | SH2 domain superfamily | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, Fes/Fps type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F8W425
|
826 | |||||||||||||
|
UniProtKB:A0A8M2BDT6
|
835 | |||||||||||||
|
UniProtKB:A0A2R8Q7T0
|
826 |
Interactions and Pathways
No data available
Plasmids
No data available