Gene
rasgrf1
- ID
- ZDB-GENE-090311-28
- Name
- Ras protein specific guanine nucleotide releasing factor 1
- Symbol
- rasgrf1 Nomenclature History
- Previous Names
-
- si:ch211-234p18.3
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to have guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of Rho protein signal transduction and small GTPase mediated signal transduction. Orthologous to human RASGRF1 (Ras protein specific guanine nucleotide releasing factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR000048 | IQ motif, EF-hand binding site |
| Conserved_site | IPR001331 | Guanine-nucleotide dissociation stimulator, CDC24, conserved site |
| Conserved_site | IPR019804 | Ras guanine-nucleotide exchange factor, conserved site |
| Domain | IPR000219 | Dbl homology (DH) domain |
| Domain | IPR000651 | Ras-like guanine nucleotide exchange factor, N-terminal |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR001895 | Ras guanine-nucleotide exchange factors catalytic domain |
| Family | IPR008937 | Ras-like guanine nucleotide exchange factor |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR023578 | Ras guanine nucleotide exchange factor domain superfamily |
| Homologous_superfamily | IPR035899 | Dbl homology (DH) domain superfamily |
| Homologous_superfamily | IPR036964 | Ras guanine-nucleotide exchange factor, catalytic domain superfamily |
Domain Details Per Protein
| Protein | Length | Dbl homology (DH) domain | Dbl homology (DH) domain superfamily | Guanine-nucleotide dissociation stimulator, CDC24, conserved site | IQ motif, EF-hand binding site | PH-like domain superfamily | Pleckstrin homology domain | Ras guanine-nucleotide exchange factor, catalytic domain superfamily | Ras guanine-nucleotide exchange factor, conserved site | Ras guanine nucleotide exchange factor domain superfamily | Ras guanine-nucleotide exchange factors catalytic domain | Ras-like guanine nucleotide exchange factor | Ras-like guanine nucleotide exchange factor, N-terminal |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:E7F7V2
|
1256 | ||||||||||||
|
UniProtKB:A0A8M3B2X9
|
1263 |
| Type | Name | Annotation Method | Length (nt) | Analysis |
|---|---|---|---|---|
| mRNA |
rasgrf1-201
(1)
|
Havana | 4177 nt |
Interactions and Pathways
No data available
Plasmids
No data available