Gene

ciita

ID
ZDB-GENE-071116-6
Name
class II, major histocompatibility complex, transactivator
Symbol
ciita Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to have activating transcription factor binding activity. Predicted to be involved in inflammatory response and positive regulation of macromolecule biosynthetic process. Human ortholog(s) of this gene implicated in Addison's disease; MHC class II deficiency; autoimmune hypersensitivity disease (multiple); myocardial infarction; and rheumatoid arthritis (multiple). Orthologous to human CIITA (class II major histocompatibility complex transactivator).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ciita Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
MHC class II deficiency Alliance Bare lymphocyte syndrome, type II, complementation group A 209920
rheumatoid arthritis Alliance {Rheumatoid arthritis, susceptibility to} 180300
Associated With ciita Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR007111 NACHT nucleoside triphosphatase
Domain IPR041267 NACHT, LRR and PYD domains-containing protein, helical domain HD2
Family IPR008095 MHC class II transactivator
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR032675 Leucine-rich repeat domain superfamily
Repeat IPR001611 Leucine-rich repeat
Domain Details Per Protein
Protein Length Leucine-rich repeat Leucine-rich repeat domain superfamily MHC class II transactivator NACHT, LRR and PYD domains-containing protein, helical domain HD2 NACHT nucleoside triphosphatase P-loop containing nucleoside triphosphate hydrolase
UniProtKB:A0A8M2BB20 1138
UniProtKB:A0A8M3AQW0 1143
UniProtKB:E7F3F4 1044
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations