Gene
atr
- ID
- ZDB-GENE-070912-458
- Name
- ATR serine/threonine kinase
- Symbol
- atr Nomenclature History
- Previous Names
-
- si:dkey-231j24.1
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to have protein serine/threonine kinase activity. Involved in several processes, including determination of left/right symmetry; intrinsic apoptotic signaling pathway in response to DNA damage; and regulation of heart looping. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in Seckel syndrome 1 and pancreatic cancer. Is expressed in hindbrain neural rod; midbrain neural rod; optic vesicle; somite; and tail bud. Orthologous to human ATR (ATR serine/threonine kinase).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Stiff et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Seckel syndrome 1 | Alliance | Seckel syndrome 1 | 210600 |
?Cutaneous telangiectasia and cancer syndrome, familial | 614564 |
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
Protein | Length |
---|---|
UniProtKB:A0A8M9P8M6
|
2077 |
UniProtKB:A0A8N7TEF8
|
2633 |
Interactions and Pathways
No data available
Plasmids
No data available