Gene

herc2

ID

ZDB-GENE-070718-6

Name

HECT and RLD domain containing E3 ubiquitin protein ligase 2

Symbol

herc2 Nomenclature History

Previous Names

fd13h10
wu:fd13h10 (1)

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to have ubiquitin-protein transferase activity and zinc ion binding activity. Predicted to be involved in protein ubiquitination. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability and pigmentation disease. Orthologous to human HERC2 (HECT and RLD domain containing E3 ubiquitin protein ligase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With herc2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive intellectual developmental disorder 38	Alliance	Intellectual developmental disorder, autosomal recessive 38	615516
		[Skin/hair/eye pigmentation 1, blond/brown hair]	227220
		[Skin/hair/eye pigmentation 1, blue/nonblue eyes]	227220

Associated With herc2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000433	Zinc finger, ZZ-type
Domain	IPR000569	HECT domain
Domain	IPR001199	Cytochrome b5-like heme/steroid binding domain
Domain	IPR004939	APC10/DOC domain
Domain	IPR010606	Mib-herc2
Domain	IPR021097	CPH domain
Domain	IPR037976	HERC2, APC10 domain
Domain	IPR041987	HERC2, zinc finger, ZZ-type
Homologous_superfamily	IPR008979	Galactose-binding-like domain superfamily
Homologous_superfamily	IPR009060	UBA-like superfamily
Homologous_superfamily	IPR009091	Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
Homologous_superfamily	IPR014722	Large ribosomal subunit protein uL2, domain 2
Homologous_superfamily	IPR035983	HECT, E3 ligase catalytic domain
Homologous_superfamily	IPR036400	Cytochrome b5-like heme/steroid binding domain superfamily
Homologous_superfamily	IPR037252	Mib/herc2 domain superfamily
Homologous_superfamily	IPR043145	Zinc finger, ZZ-type superfamily
Repeat	IPR000408	Regulator of chromosome condensation, RCC1
Repeat	IPR006624	Beta-propeller repeat TECPR

Domain Details Per Protein

Protein	Length	APC10/DOC domain	Beta-propeller repeat TECPR	CPH domain	Cytochrome b5-like heme/steroid binding domain	Cytochrome b5-like heme/steroid binding domain superfamily	Galactose-binding-like domain superfamily	HECT domain	HECT, E3 ligase catalytic domain	HERC2, APC10 domain	HERC2, zinc finger, ZZ-type	Large ribosomal subunit protein uL2, domain 2	Mib-herc2	Mib/herc2 domain superfamily	Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II	Regulator of chromosome condensation, RCC1	UBA-like superfamily	Zinc finger, ZZ-type	Zinc finger, ZZ-type superfamily
UniProtKB:A0A8M9PKG1 InterPro	2010
UniProtKB:A0A8M9QG78 InterPro	4831
UniProtKB:A0A8M9PRI1 InterPro	2009
UniProtKB:A0A8M9QB68 InterPro	4830

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	herc2-202 (1) Ensembl	Havana	2606 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations