Gene
ptpro
- ID
- ZDB-GENE-070424-54
- Name
- protein tyrosine phosphatase receptor type O
- Symbol
- ptpro Nomenclature History
- Previous Names
-
- zgc:158179
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to have protein tyrosine phosphatase activity. Involved in cerebellum morphogenesis and regulation of fibroblast growth factor receptor signaling pathway. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in nephrotic syndrome type 6. Is expressed in several structures, including brain; eye; optic cup; optic vesicle; and tail bud. Orthologous to human PTPRO (protein tyrosine phosphatase receptor type O).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Liao et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| nephrotic syndrome type 6 | Alliance | Nephrotic syndrome, type 6 | 614196 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR016130 | Protein-tyrosine phosphatase, active site |
| Domain | IPR000242 | Tyrosine-specific protein phosphatase, PTPase domain |
| Domain | IPR000387 | Tyrosine-specific protein phosphatases domain |
| Domain | IPR003595 | Protein-tyrosine phosphatase, catalytic |
| Domain | IPR003961 | Fibronectin type III |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Family | IPR042996 | Receptor-type tyrosine-protein phosphatase O |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR029021 | Protein-tyrosine phosphatase-like |
| Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
Domain Details Per Protein
| Protein | Length | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin-like domain | Immunoglobulin-like fold | Protein-tyrosine phosphatase, active site | Protein-tyrosine phosphatase, catalytic | Protein-tyrosine phosphatase-like | Receptor-type tyrosine-protein phosphatase O | Tyrosine-specific protein phosphatase, PTPase domain | Tyrosine-specific protein phosphatases domain |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A4IFW3
|
1238 |
Interactions and Pathways
No data available
Plasmids
No data available