Gene

trmt1

ID
ZDB-GENE-060810-40
Name
tRNA methyltransferase 1
Symbol
trmt1 Nomenclature History
Previous Names
  • im:7150454 (1)
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to have tRNA (guanine-N2-)-methyltransferase activity. Predicted to be involved in tRNA N2-guanine methylation. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Is expressed in several structures, including head; immature eye; mesoderm; midbrain; and neural plate. Orthologous to human TRMT1 (tRNA methyltransferase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
8 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With trmt1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal recessive intellectual developmental disorder 68 Alliance Intellectual developmental disorder, autosomal recessive 68 618302
Associated With trmt1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000571 Zinc finger, CCCH-type
Family IPR002905 tRNA methyltransferase, Trm1
Homologous_superfamily IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
Homologous_superfamily IPR036855 Zinc finger, CCCH-type superfamily
Homologous_superfamily IPR042296 tRNA methyltransferase, Trm1, C-terminal
Domain Details Per Protein
Protein Length S-adenosyl-L-methionine-dependent methyltransferase superfamily tRNA methyltransferase, Trm1 tRNA methyltransferase, Trm1, C-terminal Zinc finger, CCCH-type Zinc finger, CCCH-type superfamily
UniProtKB:A0A8M3B710 629
UniProtKB:F1QGD9 672
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations