Gene

gucy1a1

ID

ZDB-GENE-050417-230

Name

guanylate cyclase 1 soluble subunit alpha 1

Symbol

gucy1a1 Nomenclature History

Previous Names

gucy1a3
im:7136149
zgc:112159 (1)

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to have guanylate cyclase activity and nucleotide binding activity. Involved in inflammatory response to wounding. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in Moyamoya disease. Is expressed in diencephalon and floor plate. Orthologous to human GUCY1A1 (guanylate cyclase 1 soluble subunit alpha 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

IMAGE:7136149 (14 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Vishnolia et al., 2021
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gucy1a1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Moyamoya disease	Alliance	Moyamoya 6 with achalasia	615750

Associated With gucy1a1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018297	Adenylyl cyclase class-4/guanylyl cyclase, conserved site
Domain	IPR001054	Adenylyl cyclase class-3/4/guanylyl cyclase
Domain	IPR011645	Haem NO binding associated
Homologous_superfamily	IPR029787	Nucleotide cyclase
Homologous_superfamily	IPR038158	H-NOX domain superfamily
Homologous_superfamily	IPR042463	Haem NO binding associated domain superfamily

Domain Details Per Protein

Protein	Length	Adenylyl cyclase class-3/4/guanylyl cyclase	Adenylyl cyclase class-4/guanylyl cyclase, conserved site	Haem NO binding associated	Haem NO binding associated domain superfamily	H-NOX domain superfamily	Nucleotide cyclase
UniProtKB:E7EZW5 InterPro	679

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	gucy1a1-201 (1) Ensembl	Havana	2769 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	gucy1a3-003 (1) Ensembl	Havana	1943 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations