Gene

adgrv1

ID

ZDB-GENE-040624-6

Name

adhesion G protein-coupled receptor V1

Symbol

adgrv1 Nomenclature History

Previous Names

vlgr1 (1)
gpr98
mass1 (1)

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to have G protein-coupled receptor activity; G-protein alpha-subunit binding activity; and adenylate cyclase inhibitor activity. Involved in eye photoreceptor cell development. Predicted to localize to integral component of membrane; photoreceptor inner segment; and stereocilium membrane. Human ortholog(s) of this gene implicated in Usher syndrome type 2C and familial febrile seizures 4. Is expressed in integument; nervous system; and pleuroperitoneal region. Orthologous to human ADGRV1 (adhesion G protein-coupled receptor V1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 5 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

IMAGE:7139473 (6 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With adgrv1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
familial febrile seizures 4	Alliance	?Febrile seizures, familial, 4	604352
Usher syndrome type 2C	Alliance	Usher syndrome, type 2C	605472
Usher syndrome type 2C	Alliance	Usher syndrome, type 2C, GPR98/PDZD7 digenic	605472

Associated With adgrv1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR000203	GPS motif
Domain	IPR003609	PAN/Apple domain
Domain	IPR003644	Na-Ca exchanger/integrin-beta4
Domain	IPR006558	LamG-like jellyroll fold
Domain	IPR017981	GPCR, family 2-like, 7TM
Family	IPR000832	GPCR, family 2, secretin-like
Family	IPR026919	Adhesion G-protein coupled receptor V1
Homologous_superfamily	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily
Homologous_superfamily	IPR038081	CalX-like domain superfamily
Homologous_superfamily	IPR046338	GAIN domain superfamily
Repeat	IPR009039	EAR