Gene

mus81

ID
ZDB-GENE-040426-2923
Name
MUS81 structure-specific endonuclease subunit
Symbol
mus81 Nomenclature History
Previous Names
  • wu:fc26g01
  • zgc:66489
  • zgc:91801
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to contribute to crossover junction endodeoxyribonuclease activity. Predicted to be involved in double-strand break repair via break-induced replication; intra-S DNA damage checkpoint; and resolution of meiotic recombination intermediates. Predicted to localize to Holliday junction resolvase complex and nucleus. Orthologous to human MUS81 (MUS81 structure-specific endonuclease subunit).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mus81 Human Ortholog
No data available
Associated With mus81 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR006166 ERCC4 domain
Domain IPR047416 MUS81, XPF-like nuclease domain
Domain IPR047417 MUS81, winged helix domain
Family IPR033309 Crossover junction endonuclease Mus81
Homologous_superfamily IPR011335 Restriction endonuclease type II-like
Homologous_superfamily IPR027421 DNA polymerase lambda lyase domain superfamily
Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
Homologous_superfamily IPR042530 EME1/EME2, C-terminal domain
Domain Details Per Protein
Protein Length Crossover junction endonuclease Mus81 DNA polymerase lambda lyase domain superfamily EME1/EME2, C-terminal domain ERCC4 domain MUS81, winged helix domain MUS81, XPF-like nuclease domain Restriction endonuclease type II-like Winged helix-like DNA-binding domain superfamily
UniProtKB:Q6GML8 612
UniProtKB:Q7SXA9 604
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations