Gene

mccc2

ID

ZDB-GENE-040426-2493

Name

methylcrotonyl-CoA carboxylase subunit 2

Symbol

mccc2 Nomenclature History

Previous Names

si:dkey-57m14.1 (1)
zgc:85685

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to contribute to methylcrotonoyl-CoA carboxylase activity. Predicted to be involved in leucine catabolic process. Predicted to localize to methylcrotonoyl-CoA carboxylase complex and mitochondrion. Human ortholog(s) of this gene implicated in 3-Methylcrotonyl-CoA carboxylase 2 deficiency and mitochondrial metabolism disease. Orthologous to human MCCC2 (methylcrotonoyl-CoA carboxylase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:85685 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mccc2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
3-Methylcrotonyl-CoA carboxylase 2 deficiency	Alliance	3-Methylcrotonyl-CoA carboxylase 2 deficiency	210210

Associated With mccc2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR011762	Acetyl-coenzyme A carboxyltransferase, N-terminal
Domain	IPR011763	Acetyl-coenzyme A carboxyltransferase, C-terminal
Domain	IPR034733	Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta
Family	IPR045190	Methylcrotonoyl-CoA carboxylase beta chain MCCB/AccD1-like
Homologous_superfamily	IPR029045	ClpP/crotonase-like domain superfamily

Domain Details Per Protein

Protein	Length	Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta	Acetyl-coenzyme A carboxyltransferase, C-terminal	Acetyl-coenzyme A carboxyltransferase, N-terminal	ClpP/crotonase-like domain superfamily	Methylcrotonoyl-CoA carboxylase beta chain MCCB/AccD1-like
UniProtKB:Q6NWI5 InterPro	566

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	mccc2-201 (1) Ensembl	Havana	2037 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	mccc2-002 (1) Ensembl	Havana	290 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations