Gene

myd88

ID

ZDB-GENE-040219-3

Name

MYD88 innate immune signal transduction adaptor

Symbol

myd88 Nomenclature History

Previous Names

zMyD88 (1)
zgc:103541

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Predicted to have Toll-like receptor binding activity. Involved in several processes, including neutrophil activation involved in immune response; neutrophil chemotaxis; and response to bacterium. Predicted to localize to plasma membrane. Human ortholog(s) of this gene implicated in Waldenstroem's macroglobulinemia. Is expressed in several structures, including digestive system; hematopoietic system; pleuroperitoneal region; tail bud; and ventral fin fold. Orthologous to human MYD88 (MYD88 innate immune signal transduction adaptor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

23 figures from 16 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 14 figures from 9 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With myd88 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
lymphoplasmacytic lymphoma	Alliance	Macroglobulinemia, Waldenstrom, somatic	153600
		Immunodeficiency 68	612260

Associated With myd88 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000157	Toll/interleukin-1 receptor homology (TIR) domain
Domain	IPR000488	Death domain
Domain	IPR034249	MyD88, death domain
Family	IPR017281	Myeloid differentiation primary response protein MyD88
Homologous_superfamily	IPR011029	Death-like domain superfamily
Homologous_superfamily	IPR035897	Toll/interleukin-1 receptor homology (TIR) domain superfamily